1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole

Basic Information

CAS No.	110963-63-8
EC No.	Not available
Linear Formula	C16H23N3O
Molecular Weight	273.37
Appearance	Off-white to light brown solid
Melting Point	Not available (typical reference)
Boiling point	452 ± 40 °C (predicted, lit.)
Density	1.18 g/mL (predicted, lit.)
Solubility	Soluble in organic solvents including DMSO, methanol, and dichloromethane; limited solubility in water
Storage Conditions	Keep in a tightly closed container at 2-8°C, protected from light
Chemical Structure

Key Applications

• Pharmaceutical intermediate: Serves as a core building block in the synthesis of bilastine, a second-generation antihistamine active pharmaceutical ingredient, and an important component within Bilastine and specialty antihistamine intermediates for pharmaceutical development.

• API intermediate: Enables attachment of the ethoxyethyl group to the benzimidazole-piperidine framework essential for bilastine structure, making it relevant to piperazine and piperidine intermediates in API synthesis.

• Heterocyclic synthesis: Provides a functionalized benzimidazole scaffold for constructing complex nitrogen-heterocyclic systems in organic synthesis, especially among quinazolinone, benzimidazole and fused heterocycle intermediates.

• Medicinal chemistry research: Applied in the preparation of analogs and derivatives for antihistamine and related therapeutic explorations.

• Process development: Facilitates route evaluation and optimization for scalable production of high-purity pharmaceutical intermediates for API synthesis.

• Consistent product quality: Purity and key parameters controlled via standard analytical methods to provide dependable performance in synthetic workflows.

• Stable global supply: Robust supply arrangements ensure continuous availability from small research quantities to larger commercial needs.

• SDS and COA support: Comprehensive SDS and COA documentation prepared and provided to meet quality and regulatory expectations.

• Packaging and technical service: Packaging tailored in 1kg, 5kg, or 25kg options with suitable liners, supported by prompt technical discussions.