5-Formyl-2,4-dimethylpyrrole-3-carboxylic acid

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid is a functionalized pyrrole derivative featuring both aldehyde and carboxylic acid groups. This dual functionality makes it highly useful for condensation and amidation reactions in controlled synthetic sequences.

Basic Information

CAS No.	253870-02-9
EC No.	607-716-8
Linear Formula	C8H9NO3
Molecular Weight	167.16
Appearance	Yellow crystalline powder
Melting Point	283 °C (lit.)
Boiling point	374.9±42.0 °C (Predicted)
Density	1.342±0.06 g/cm³ (Predicted)
Solubility	Slightly soluble in DMSO, methanol, and aqueous base (typical reference)
Storage Conditions	Keep in dark place, sealed in dry, room temperature
Chemical Structure

Key Applications

• Pharmaceutical intermediate: An essential building block in the multi-step synthesis of sunitinib, a multi-kinase inhibitor used in oncology, and a relevant component within Gefitinib, Sunitinib and Sorafenib intermediates for targeted therapy development.

• API intermediate: Employed in the manufacture of active pharmaceutical ingredients targeting receptor tyrosine kinases, especially in the broader category of oncology drug intermediates used for anticancer API synthesis.

• Heterocyclic synthesis: Provides a versatile pyrrole core for constructing substituted nitrogen-containing aromatic frameworks used in pharmaceutical intermediate design and optimization.

• Laboratory research: Utilized in medicinal chemistry programs for exploring novel kinase inhibitor analogs and related oncology-focused small molecules.

• Process development: Applied in route scouting, optimization, and scale-up studies for fine chemical production and pharmaceutical intermediates for API synthesis.

• Consistent product quality: High purity levels and batch-to-batch uniformity verified through standard analytical methods suitable for pharmaceutical intermediate use.

• Flexible global supply: Stable export arrangements with established logistics supporting laboratory, pilot, and production-scale quantities.

• SDS and COA support: Full safety data sheets and certificates of analysis provided promptly for compliance and quality assurance.

• Packaging and technical service: Flexible options including 1kg, 5kg, or 25kg fiber drums with PE liners together with responsive technical assistance.