Dibenzo[b,f][1,4]thiazepin-11(10H)-one

10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine is a heterocyclic compound widely recognized as a crucial building block in organic synthesis. It features a dibenzothiazepine core with a lactam functionality, making it suitable for further derivatization in controlled environments.

Basic Information

CAS No.	3159-07-7
EC No.	608-646-0 / 438-020-0
Linear Formula	C13H9NOS
Molecular Weight	227.28
Appearance	White to off-white powder to crystal
Melting Point	265 °C (lit.)
Boiling point	309.2±12.0 °C (Predicted)
Density	1.292±0.06 g/cm³ (Predicted)
Solubility	Soluble in DMSO; limited solubility in common organic solvents (typical reference)
Storage Conditions	Keep in dark place, sealed in dry, 2-8°C
Chemical Structure

Key Applications

• Quetiapine intermediate: A key intermediate in the synthesis of quetiapine and related atypical antipsychotic compounds, and an important building block within quetiapine intermediates for process development.

• Pharmaceutical synthesis: Used for constructing dibenzothiazepine-based active pharmaceutical ingredients and related CNS drug intermediates in antipsychotic discovery and manufacturing.

• Fused heterocycle building block: Serves as a useful scaffold for heterocyclic frameworks in organic synthesis, especially among quinazolinone, benzimidazole and fused heterocycle intermediates used in API development.

• Process and route development: Applied in laboratory research, route scouting, and process development for fine chemicals and pharmaceutical intermediates for API synthesis.

• Custom synthesis support: Employed in custom synthesis projects requiring high-purity thiazepine derivatives for pharmaceutical and advanced heterocyclic applications.

High-purity product with batch-to-batch consistency verified through standard QC protocols.

Stable global supply chain supporting exports with dependable lead times for various scales.

Full documentation including SDS, COA, and additional certificates provided upon request.

Responsive technical support and flexible packaging options such as 1kg, 5kg, or 25kg fiber drums with PE liners, customized as needed.