4-Chloro-N-methylpicolinamide

4-Chloro-N-methylpicolinamide is a chlorinated pyridine derivative with an N-methyl carboxamide substituent. This structure enables selective nucleophilic aromatic substitution in multi-step synthetic pathways.

Basic Information

CAS No.	220000-87-3
EC No.	606-888-1
Linear Formula	C7H7ClN2O
Molecular Weight	170.60
Appearance	Pale yellow to white solid / powder
Melting Point	41-43 °C (lit.)
Boiling point	317.8±27.0 °C (Predicted)
Density	1.264±0.06 g/cm³ (Predicted)
Solubility	Soluble in methanol; slightly soluble in common organic solvents (typical reference)
Storage Conditions	Keep in dark place, sealed in dry, room temperature
Chemical Structure

Key Applications

• Pharmaceutical intermediate: A critical precursor in the synthesis of sorafenib, a multi-kinase inhibitor for oncology applications, and an important building block within Gefitinib, Sunitinib and Sorafenib intermediates for targeted therapy development.

• API intermediate: Used in the preparation of active pharmaceutical ingredients involving substituted pyridine scaffolds, especially among oncology drug intermediates for anticancer API synthesis.

• Heterocyclic synthesis: Facilitates construction of pyridine-based aromatic systems through amide and chloro group transformations in pharmaceutical and fine chemical synthesis.

• Process development: Employed in route optimization and scale-up for efficient production of fine chemical intermediates and downstream pharmaceutical building blocks.

• Custom synthesis: Applied in tailored projects requiring high-purity chlorinated picolinamides for research use and pharmaceutical intermediates for API synthesis.

• High product consistency: Maintained through strict quality controls and analytical verification for reproducible performance in intermediate synthesis.

• Stable international supply: Supported by reliable logistics networks for timely delivery to global pharmaceutical and fine chemical clients.

• Comprehensive documentation: SDS, COA, and other supporting documents supplied as standard to meet regulatory and quality needs.

• Technical and packaging flexibility: Expert guidance on applications combined with options like 1kg/5kg/25kg packing in fiber drums or customized formats.