6-Acetoxy-7-methoxy-3H-quinazolin-4-one

6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4(3H)-one is a substituted quinazolinone derivative commonly utilized as a protected intermediate in heterocyclic synthesis. Its acetoxy group at the 6-position allows for selective functionalization in multi-step processes.

Basic Information

CAS No.	179688-53-0
EC No.	808-050-2
Linear Formula	C11H10N2O4
Molecular Weight	234.21
Appearance	Very pale yellow to pale yellow crystal - powder
Melting Point	297 °C (lit.)
Boiling point	390.5±52.0 °C (Predicted)
Density	1.39 g/cm³ (Predicted)
Solubility	Slightly soluble in hot DMF; limited in common solvents (typical reference)
Storage Conditions	Store in a cool, dark place, sealed, recommended <15°C
Chemical Structure

Key Applications

• Gefitinib intermediate: Serves as a critical building block in the multi-step synthesis of gefitinib, an EGFR tyrosine kinase inhibitor used in oncology, and fits naturally within Gefitinib, Sunitinib and Sorafenib intermediates for targeted therapy development.

• Pharmaceutical synthesis: Employed in the preparation of quinazoline-based active pharmaceutical ingredients and related therapeutic compounds, especially among oncology drug intermediates used in anticancer API synthesis.

• Heterocyclic construction: Provides a protected quinazolinone scaffold for further elaboration in aromatic and nitrogen-containing molecule assembly, making it relevant to quinazolinone, benzimidazole and fused heterocycle intermediates.

• Process development: Utilized in laboratory route scouting, optimization, and scale-up studies for fine chemicals and pharmaceutical intermediates for API synthesis.

• Custom synthesis: Applied in bespoke projects requiring high-purity acetoxy-substituted quinazolinones for research and advanced pharmaceutical development.

• Product quality consistency: Batch-to-batch uniformity maintained through rigorous in-house quality controls suitable for pharmaceutical intermediate applications.

• Global supply stability: Dependable export capabilities with established channels ensuring timely delivery across scales from lab to pilot quantities.

• Documentation support: Comprehensive SDS, COA, and related certificates readily provided to facilitate sourcing, compliance, and quality verification.

• Technical and packaging service: Expert assistance available for technical inquiries, along with flexible options such as 1kg/5kg/25kg fiber drums with PE liners or customized packaging.