1-[2-(2-Hydroxyethoxy)ethyl]piperazine

Product Description

1-[2-(2-Hydroxyethoxy)ethyl]piperazine is a hydroxyethyl-substituted piperazine featuring an ethoxyethanol side chain. This bifunctional structure with secondary amine and primary alcohol groups allows for versatile reactivity in alkylation and esterification processes.

Basic Information

CAS No.	13349-82-1
EC No.	603-746-0
Linear Formula	C8H18N2O2
Molecular Weight	174.24
Appearance	Clear colorless to yellow-brownish liquid
Melting Point	Not available (typical reference)
Boiling point	112-114 °C at 0.25 mmHg (lit.)
Density	1.061 g/mL at 25 °C (lit.)
Solubility	Soluble in acetone, chloroform, methanol; miscible with water (typical reference)
Storage Conditions	Keep in dark place, inert atmosphere, room temperature
Chemical Structure

Key Applications

• Pharmaceutical intermediate: An essential building block in the multi-step synthesis of quetiapine, this compound is also relevant to broader Quetiapine intermediates process development and route design.

• API intermediate: Used in the preparation of active pharmaceutical ingredients containing piperazine-ethoxyethanol linkages, making it a useful building block among piperazine and piperidine intermediates for pharmaceutical synthesis.

• Functional molecule construction: Serves as a linker with amine and alcohol functionalities for assembling complex nitrogen-containing structures used in pharmaceutical intermediates for API synthesis.

• Laboratory research: Employed in medicinal chemistry for exploring piperazine-based analogs and derivatives, especially in the development of CNS drug intermediates for antipsychotic and CNS-active molecules.

• Process development: Applied in route optimization and scale-up studies for efficient production of fine chemical intermediates related to quetiapine and other structurally similar pharmaceutical targets.

• Product consistency assurance: High purity maintained with batch uniformity through rigorous QC protocols ideal for pharmaceutical intermediate use.

• Stable global logistics: Dependable export support via established channels for seamless supply from lab to production scales.

• Full documentation service: SDS, COA, and supporting certificates provided to facilitate quality verification and compliance.

• Flexible packaging and support: Options including 1kg/5kg/25kg HDPE drums or cartons with liners, complemented by responsive technical expertise.