1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

Basic Information

CAS No.	6969-71-7
EC No.	230-191-8
Linear Formula	C6H5N3O
Molecular Weight	135.12
Appearance	White to off-white crystalline powder
Melting Point	231-235 °C (lit.)
Boiling point	Not available (typical reference)
Density	1.51 g/mL (predicted, lit.)
Solubility	Soluble in DMSO and methanol; slightly soluble in water
Storage Conditions	Store at 2-8°C in a tightly closed container, protected from light
Chemical Structure

Key Applications

• Pharmaceutical intermediate: A key precursor in the synthesis of trazodone, an antidepressant active pharmaceutical ingredient, and a relevant building block within CNS drug intermediates for neuropsychiatric pharmaceutical development.

• API intermediate: Facilitates construction of the triazolopyridine core essential for certain CNS therapeutics and related heterocyclic pharmaceutical targets.

• Heterocyclic synthesis: Serves as a building block for fused triazole-pyridine systems in advanced organic synthesis, especially among quinazolinone, benzimidazole and fused heterocycle intermediates.

• Laboratory research: Utilized in exploratory studies and analog preparation within medicinal chemistry programs involving CNS-active and fused heterocyclic compounds.

• Process development: Supports route optimization and scale-up efforts for heterocyclic pharmaceutical intermediates and pharmaceutical intermediates for API synthesis.

• Consistent product quality: High purity levels verified through routine analysis to ensure batch reliability for precise synthetic requirements.

• Stable global supply: Established channels provide consistent availability from gram-scale research to larger production volumes worldwide.

• SDS and COA support: Full SDS, COA, and analytical reports available on request to streamline quality and compliance processes.

• Packaging and technical service: Flexible options including 1kg, 5kg, or 25kg fiber drums with PE liner, supported by dedicated technical assistance.