1-Phenyl-1-cyclopentanecarboxylic acid

1-Phenyl-1-cyclopentanecarboxylic acid is a geminal-substituted cyclopentane carboxylic acid bearing a phenyl group at the alpha position. Its rigid cyclic structure and carboxylic functionality make it suitable for amidation, esterification, and other derivatization steps in organic synthesis.

Basic Information

CAS No.	77-55-4
EC No.	201-041-0
Linear Formula	C12H14O2
Molecular Weight	190.24
Appearance	White to off-white crystalline powder
Melting Point	158-161 °C (lit.)
Boiling point	340 °C (lit.)
Density	1.15 g/cm³ (Predicted)
Solubility	Slightly soluble in water; soluble in ethanol, acetone, and chloroform (typical reference)
Storage Conditions	Keep in a tightly closed container in a cool, dry place, room temperature
Chemical Structure

Key Applications

• Pharmaceutical intermediate: Used as a key building block in the synthesis of various central nervous system-active compounds and related pharmaceuticals, making it relevant to CNS drug intermediates for pharmaceutical development.

• API intermediate: Employed in the preparation of active pharmaceutical ingredients featuring cyclopentyl-phenyl motifs, with practical value in pharmaceutical intermediate supply where quality consistency and supporting documentation are important.

• Functional molecule construction: Provides a sterically hindered carboxylic acid scaffold for amide and ester derivative synthesis in pharmaceutical and fine chemical applications.

• Laboratory research: Applied in medicinal chemistry studies exploring conformationally restricted analogs and related structure-activity relationships.

• Custom synthesis: Utilized in bespoke projects requiring high-purity gem-disubstituted cyclopentane carboxylic acids for pharmaceutical intermediates for API synthesis.

• Batch quality consistency: Ensured through standardized production and analytical verification for reproducible results in fine chemical synthesis.

• Global delivery stability: Supported by proven international logistics for on-time supply from research to pilot quantities.

• Documentation support: SDS, COA, and additional certificates furnished promptly for sourcing and regulatory purposes.

• Technical and packaging options: Professional guidance available with flexible packaging such as 1kg/5kg/25kg fiber drums with PE liners or customized upon request.