Tris(triphenylphosphine)ruthenium(II) Dichloride

Basic Information of Tris(triphenylphosphine)ruthenium(II) Dichloride

CAS No.	15529-49-4
EC No.	239-569-8
Chemical Formula	RuCl₂(P(C₆H₅)₃)₃
Molecular Weight	958.83 g/mol
Appearance	Dark purple to black crystalline powder
Odor	Odorless
Melting point	Decomposes >200 °C
Boiling point	Not applicable (decomposes)
Density	approx. 1.5–1.7 g/cm³
Solubility	Insoluble in water; soluble in benzene, toluene, dichloromethane, chloroform, THF
Nature (hazards)	Harmful if swallowed, may cause long lasting harmful effects to aquatic life, air-sensitive in solution
RIDADR	Not regulated (not subject to transport regulations as hazardous material in many classifications)
Chemical Structure

Primary Applications of Tris(triphenylphosphine)ruthenium(II) Dichloride

RuCl₂(PPh₃)₃ is a foundational Ru(II) precatalyst, delivering outstanding performance in reduction and functionalization reactions across fine chemicals and pharmaceuticals.

1. Hydrogenation of Unsaturated Bonds
   Catalyzes efficient reduction of alkenes, alkynes, and aromatic rings under mild conditions, offering high selectivity in complex molecule synthesis for pharmaceutical intermediates.

2. Transfer Hydrogenation
   Enables selective reduction of carbonyls, imines, and nitro groups using formate or isopropanol as hydrogen donors, providing a mild, hydrogen-gas-free alternative in fine chemical production.

3. C–H Activation & Functionalization
   Facilitates Ru-catalyzed direct C–H arylation, alkenylation, and annulation of arenes and heterocycles, delivering atom-economical routes to functionalized molecules.

4. Hydroformylation & Carbonylation
   Serves as a precursor for Ru-catalyzed hydroformylation of alkenes to aldehydes and related carbonylation processes, complementing rhodium-based systems in specialty chemicals.

5. Pharmaceutical & Natural Product Synthesis
   Widely applied in reduction, deprotection, and functionalization steps of active pharmaceutical ingredients and natural products, offering scalability and functional group tolerance.

6. Catalyst Development & Mechanistic Studies
   Acts as a standard Ru(II) source for ligand screening, cluster formation, and mechanistic investigations in academic and industrial catalysis R&D.

• High Purity & Ligand Integrity
  Rigorous quality controls ensure uniform Ru content, minimal free PPh₃ or impurities, and preserved coordination sphere for maximum catalytic activity.

• Secure Precious Metal Sourcing
  Transparent, responsible ruthenium procurement with inventory buffering to provide supply stability and competitive pricing.

• Technical Catalysis Support
  Dedicated specialists offer reaction optimization, co-catalyst/ligand screening, scale-up guidance, and troubleshooting to maximize efficiency and selectivity.

• Comprehensive Regulatory Compliance
  Full COA, REACH, RoHS, and detailed SDS documentation to facilitate seamless integration into global pharmaceutical and fine chemical operations.

• Sustainability & Recycling Programs
  Ethical sourcing practices and ruthenium recovery/recycling options aligned with ESG goals and sustainable chemistry principles.

Hazards Classification

• GHS Classification: Acute Toxicity, Oral (Category 4); Aquatic Chronic (Category 4)

• Hazard Statements: H302: Harmful if swallowed; H413: May cause long lasting harmful effects to aquatic life

• UN Number: Not regulated

• Hazard Class: Not classified as hazardous for transport

• Packing Group: Not applicable