Decaethylene Glycol

Decaethylene glycol, also known as PEG-10 or HO-PEG10-OH, is a defined polyethylene glycol derivative consisting of ten ethylene oxide repeating units with terminal hydroxyl groups. This monodisperse PEG diol functions as a versatile hydrophilic building block for molecular linker design and functional PEG derivative synthesis in fine chemical applications.

Basic Information

CAS No.	5579-66-8
EC No.	226-962-3
Linear Formula	HO(CH2CH2O)10H
Molecular Weight	458.54 g/mol
Appearance	White or colorless to almost white or almost colorless powder to lump to clear liquid
Melting Point	28 °C (lit.)
Boiling point	280 °C / 7 mmHg (lit.)
Density	1.115 g/cm³ (predicted)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Store sealed at room temperature.
Chemical Structure

Key Applications

• PEG linker intermediate: Decaethylene glycol serves as a precise ten-unit hydrophilic linker for bioconjugation, PEGylation strategies, and the construction of targeted delivery systems in pharmaceutical intermediate research.

• Hydrophilic spacer: The extended PEG10 chain provides an effective hydrophilic spacer that improves solubility, flexibility, and biocompatibility in complex molecular designs during fine chemical and specialty synthesis.

• Fine chemical intermediate: Functions as a versatile polyether diol building block for introducing hydrophilic segments and enabling further functionalization of terminal hydroxyl groups in organic synthesis projects.

• Laboratory research: Widely utilized in medicinal chemistry and materials research laboratories for developing PEG-based architectures, surface modifications, and novel functional linkers.

• Process development: Supports route optimization, scale-up studies, and custom synthesis of PEGylated advanced intermediates for pharmaceutical and specialty chemical process development.

• Consistent product quality: High-purity specifications with reliable batch-to-batch consistency, supported by routine quality coordination suitable for fine chemical research and process applications.

• Flexible global supply: Stable export supply supported by established logistics channels, enabling timely delivery for laboratory, pilot-scale, and bulk procurement needs worldwide.

• SDS and COA support: Comprehensive documentation including SDS and COA available upon request to facilitate sourcing, export compliance, and quality review processes.

• Packaging and technical service: Flexible packaging options tailored to product form and order quantity, combined with responsive technical communication for customer support.

Packaging and Storage

• Packaging: Available in small quantities in sealed containers or bottles; larger quantities supplied in fiber drums with inner PE liners or customized packaging configurations upon request.

• Storage: Store in a tightly closed container in a cool, dry, and well-ventilated area. Protect from moisture; recommended storage at room temperature in sealed, dry conditions.

• Handling of opened containers: Reseal containers immediately after use and return to recommended storage conditions to prevent moisture uptake and maintain product integrity.

Safety and Handling

• General handling: Handle in accordance with good industrial hygiene practices in well-ventilated areas. Avoid direct contact with skin, eyes, and clothing; prevent ingestion or inhalation.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing. Use respiratory protection if dust, aerosol, or vapors are generated during handling.

• Documentation review: Always review the latest Safety Data Sheet (SDS) before handling, storage, transportation, or use to ensure appropriate safety measures are followed.