Octaethylene Glycol

Octaethylene glycol, also known as HO-PEG8-OH, is a well-defined polyethylene glycol oligomer with exactly eight ethylene oxide units and terminal hydroxyl groups. Its discrete chain length makes it a practical hydrophilic building block for constructing spacers and linkers in organic synthesis and related research fields.

Basic Information

CAS No.	5117-19-1
EC No.	225-856-4
Linear Formula	HO(CH2CH2O)8H
Molecular Weight	370.44 g/mol
Appearance	White or colorless to light yellow powder to lump to clear liquid
Melting Point	22 °C (lit.)
Boiling point	175 °C at 0.01 Torr (lit.)
Density	1.13 g/mL (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture.
Chemical Structure

Key Applications

• PEG linker intermediate: Octaethylene glycol provides a precise eight-unit hydrophilic chain suitable for building defined molecular linkers and spacers in bioconjugation and surface modification research.

• Molecular linker intermediate: The symmetric diol structure acts as a versatile starting material for preparing heterobifunctional PEG derivatives used in advanced organic synthesis and functional molecule construction.

• Fine chemical intermediate: It is applied in the synthesis of specialty polyether compounds and advanced intermediates for pharmaceutical and process chemistry projects.

• Bioconjugation research: Researchers employ this compound to introduce consistent hydrophilic segments into target molecules for studies involving conjugates and biomolecular probes.

• Process development: Octaethylene glycol supports route optimization and custom synthesis work where well-characterized PEG spacers with fixed chain length are required.

• Consistent product quality: Supplied with purity specifications in the 97%~99% range and reliable batch consistency suitable for fine chemical synthesis and research applications, supported by dedicated quality coordination.

• Flexible global supply: We arrange stable export logistics and accommodate quantities from laboratory samples through pilot scale to bulk orders for customers worldwide.

• SDS and COA support: Comprehensive documentation including Safety Data Sheets and Certificates of Analysis is available to assist with quality review, regulatory needs, and international procurement.

• Packaging and technical service: Guidance on suitable packaging options based on product form and order volume is provided, along with responsive technical communication for sourcing projects.

Packaging and Storage

• Packaging: Laboratory quantities are supplied in sealed glass or HDPE bottles, while bulk orders use appropriate drums or containers selected according to volume and product characteristics.

• Storage: Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and direct light to preserve product quality.

• Handling of opened containers: Reseal containers immediately after use and return to recommended storage conditions; minimize exposure to air or potential contaminants.

• Bulk supply: Customized packaging arrangements for pilot-scale and larger volumes are available to align with specific handling and shipping requirements.

Safety and Handling

• General handling: Perform handling operations in a well-ventilated area using standard practices appropriate for chemical reagents and fine chemical materials.

• Personal protection: Wear suitable protective gloves, safety goggles, and clothing to avoid direct contact with skin or eyes during handling.

• Documentation review: Consult the latest Safety Data Sheet (SDS) for detailed handling, storage, first aid, and disposal information before any use or transport.

• Compatibility: Avoid strong oxidizing agents and review the full product documentation for specific compatibility considerations with other materials.