Hexaethylene glycol

Its terminal hydroxyl functionality supports further derivatization, making it a valuable building block for constructing PEGylated intermediates in pharmaceutical and specialty chemical development.

Basic Information

CAS No.	2615-15-8
EC No.	220-045-1
Linear Formula	HO(CH2CH2O)6H
Molecular Weight	282.33 g/mol
Appearance	Clear colorless to pale yellow viscous liquid
Melting Point	5-7 °C (lit.)
Boiling point	217 °C at 4 mmHg (lit.)
Density	1.127 g/mL at 25 °C (lit.)
Solubility	Miscible with water; soluble in polar organic solvents such as methanol and chloroform
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage at 2–8 °C.
Chemical Structure

Key Applications

• PEG linker intermediate: The extended six-unit polyether chain with terminal hydroxyl groups offers a longer hydrophilic spacer for linker design in bioconjugation and surface modification applications.

• Molecular linker intermediate: Acts as a flexible polyether bridge in the construction of functional molecules and complex organic structures.

• Fine chemical intermediate: Employed as a building block for specialty PEG derivatives used in advanced chemical synthesis.

• Laboratory research: Widely utilized in research settings for developing PEGylated compounds and studying their physicochemical properties.

• Process development: Facilitates route optimization and scale-up efforts in the preparation of PEG-containing pharmaceutical intermediates and specialty materials.

• Consistent product quality: Offered at 98% purity with consistent batch quality supported by routine quality coordination for fine chemical applications.

• Flexible global supply: Enables stable export supply through established logistics channels for laboratory, pilot and bulk scale requirements.

• SDS and COA support: Comprehensive SDS and COA documentation is available to support sourcing, export compliance and quality review processes.

• Packaging and technical service: Provides flexible packaging options and responsive technical communication tailored to customer application needs.

Packaging and Storage

• Packaging: Supplied in 1 kg and 5 kg laboratory bottles or 25 L and 200 L HDPE drums depending on order size. Customized liquid packaging available upon request.

• Storage: Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials.

• Handling of opened containers: Reseal containers immediately after use and maintain under recommended storage conditions to preserve product quality.

• Bulk supply: Appropriate packaging and scheduling available for pilot-scale trials and commercial bulk orders.

Safety and Handling

• General handling: Follow good industrial hygiene and safety practices. Minimize direct contact and avoid inhalation of vapors or mists.

• Personal protection: Wear suitable protective gloves, safety goggles and protective clothing when handling the product.

• Documentation review: Always consult the latest Safety Data Sheet (SDS) prior to handling, storage, transportation or use.

• Compatibility: Incompatible with strong oxidizing agents. Review compatibility with other materials before combining or processing.