2-[2-(2-Aminoethoxy)ethoxy]ethanol

2-[2-(2-Aminoethoxy)ethoxy]ethanol, commonly known as NH2-PEG3-OH or Amino-PEG3-alcohol, is a bifunctional polyethylene glycol derivative featuring both amino and hydroxyl terminal groups on a short triethylene glycol spacer. This well-defined small-molecule PEG linker is widely utilized in organic synthesis and bioconjugation applications requiring precise hydrophilic spacing and selective functionalization.

Basic Information

CAS No.	6338-55-2
EC No.	804-174-6
Linear Formula	H2N(CH2CH2O)2CH2CH2OH
Molecular Weight	149.19 g/mol
Appearance	Colorless to light yellow to light orange clear liquid
Melting Point	Not available (typical reference)
Boiling point	100 °C / 0.1 mmHg (lit.)
Density	1.08 g/cm³ (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and carbon dioxide. Recommended storage below 15 °C.
Chemical Structure

Key Applications

• PEG linker intermediate: NH2-PEG3-OH functions as a short bifunctional hydrophilic linker, enabling selective conjugation through the amino group while the hydroxyl terminus allows further derivatization in bioconjugation and pharmaceutical intermediate research.

• Molecular linker intermediate: The amino-hydroxy PEG3 structure provides a compact, flexible spacer for constructing functional molecules, supporting precise control over distance and solubility in organic synthesis projects.

• Fine chemical intermediate: Serves as a versatile building block for the preparation of heterobifunctional PEG derivatives and specialty reagents through selective reactions at the amino and hydroxyl end groups.

• Laboratory research: Extensively employed in medicinal chemistry and materials research laboratories for developing PEGylated compounds, surface modifications, and studying the effects of short hydrophilic linkers.

• Process development: Supports route optimization and custom synthesis of amino-functionalized PEG linkers for scale-up in fine chemical and biopharmaceutical process development.

• Consistent product quality: High-purity specifications (98%+) with reliable batch consistency, supported by routine quality coordination suitable for demanding fine chemical and bioconjugation applications.

• Flexible global supply: Established logistics channels enable stable export supply for laboratory-scale, pilot-scale, and bulk orders to customers worldwide.

• SDS and COA support: Comprehensive product documentation including SDS and COA available upon request to assist with sourcing, export compliance, and internal quality review processes.

• Packaging and technical service: Customized packaging solutions based on quantity and product form, combined with responsive technical communication to meet specific application and sourcing requirements.

Packaging and Storage

• Packaging: Supplied in small quantities in sealed sample bottles or vials; larger quantities available in suitable liquid packaging or customized containers upon request.

• Storage: Store in a tightly closed container in a cool, dry, and well-ventilated area. Protect from moisture and carbon dioxide; recommended storage temperature below 15 °C.

• Handling of opened containers: Reseal containers immediately after use under inert atmosphere if possible and return to recommended storage conditions to maintain product stability and prevent moisture absorption.

Safety and Handling

• General handling: Handle in well-ventilated areas following standard laboratory and industrial safety practices. Avoid contact with skin, eyes, and clothing; prevent ingestion and inhalation of vapors.

• Personal protection: Wear suitable chemical-resistant gloves, safety goggles, and protective clothing. Use respiratory protection if vapors or aerosols are generated during handling.

• Documentation review: Always consult the latest Safety Data Sheet (SDS) prior to handling, storage, transportation, or use to ensure appropriate safety measures are in place.