Boron Trifluoride Tetrahydrofuran Complex

Basic Information of Boron Trifluoride Tetrahydrofuran Complex

Boron Trifluoride Tetrahydrofuran Complex (CAS No. 462-34-0) is characterized by its significant properties:

CAS No.:	462-34-0
EC No.:	207-325-9
Linear Formula:	C₄H₈BF₃O
Molecular Weight:	139.91
Appearance:	Transparent Liquid
Melting point:	11-13 °C (lit.)
Boiling point:	180 °C (lit.)
Density:	1.268 g/mL at 25 °C (lit.)
Solubility	Miscible with dimethyl formamide.
Flash Point:	198°F
Nature:	Strong Lewis acid.
RIDADR:	UN 2924 8/PG 2
Chemical Structure:

Its precise composition and catalytic strength make it an essential tool for chemists requiring efficient and selective Lewis acid catalysis.

Main Functions and Applications of Boron Trifluoride Tetrahydrofuran Complex

1. Catalyst for Organic Reactions: This complex is a cornerstone in organic chemistry, serving as a versatile and efficient Lewis acid catalyst. It promotes a wide range of reactions, including Friedel-Crafts alkylation and acylation, Diels-Alder reactions, aldol reactions, rearrangements, and epoxide openings, making it indispensable for C-C bond formations and complex molecular architectures.

2. Preparation of Pharmaceutical Products: Due to its high reactivity and selectivity, BF₃-THF is commonly employed as a catalyst in the synthesis of various pharmaceutical products. This includes facilitating key steps in the production of complex drug molecules such as cephalosporins and fluoroquinolones, where precise catalytic control is paramount.

3. Preparation of Boranes and Targeted Drugs: Beyond its role as a catalyst, BF₃-THF is an important raw material for the synthesis of various boranes (boron-hydrogen compounds) and the development of boron-containing targeted drugs. This includes applications in areas like Boron Neutron Capture Therapy (BNCT) and other novel boron-based therapeutics.

4. Pharmaceutical Intermediate: In the pharmaceutical field, BF₃-THF is also directly utilized as a crucial pharmaceutical intermediate. Its ability to readily participate in various transformations makes it a valuable building block for synthesizing more complex drug candidates and active pharmaceutical ingredients (APIs).

• Assured Purity & Performance: Our BF₃-THF undergoes stringent quality control to ensure high purity and consistent catalytic activity, vital for sensitive organic reactions and industrial processes.

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Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Corrosive (GHS05), Acute Toxicity (GHS06)

• Hazard Statements: Highly flammable liquid and vapor. Reacts violently with water. Toxic if swallowed, in contact with skin or if inhaled. Causes severe skin burns and eye damage.

• UN Number: UN 2924

• Hazard Class: 3 (Flammable Liquids), Subsidiary risk 8

• Packing Group: II