Amino-PEG4-alcohol

Amino-PEG4-alcohol (CAS 86770-74-3), also referred to as NH2-PEG4-OH, is a monodisperse bifunctional polyethylene glycol derivative. It features a primary amino group and a terminal hydroxyl group separated by a tetraethylene glycol chain, making it an effective molecular linker for a variety of synthetic applications.

Basic Information

CAS No.	86770-74-3
EC No.	846-679-4
Linear Formula	H₂N-(CH₂CH₂O)₄-H
Molecular Weight	193.24 g/mol
Appearance	Colorless to pale yellow viscous liquid or oil
Melting Point	Not available (typical reference)
Boiling point	301.6 ± 27.0 °C (Predicted)
Density	1.068 ± 0.06 g/cm³ (Predicted)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage at -20°C under inert atmosphere.
Chemical Structure

Key Applications

• PEG linker intermediate: Provides a defined tetraethylene glycol spacer with terminal amino and hydroxyl groups for constructing bioconjugates and PROTAC linkers.

• Bioconjugation research: The primary amine enables efficient coupling to carboxylic acids, NHS esters and carbonyl groups in biomolecule modification studies.

• Fine chemical intermediate: Acts as a versatile building block in organic synthesis for introducing hydrophilic polyether chains into complex molecules.

• Process development: Supports custom synthesis and route optimization efforts in pharmaceutical and specialty chemical process research.

• Laboratory research: Widely used in medicinal chemistry laboratories for developing PEGylated compounds and studying structure-activity relationships.

• Consistent product quality: High-purity Amino-PEG4-alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Supplied in laboratory-scale sealed containers or sample bottles for small quantities; bulk quantities available in HDPE drums upon request. Customized packaging options can be discussed based on specific requirements.

• Storage: Store in tightly closed containers in a cool, dry, well-ventilated area away from direct sunlight. Long-term storage is best at -20°C under an inert atmosphere due to hygroscopic nature.

• Handling of opened containers: After opening, protect the product from moisture and air exposure. Use the contents promptly and reseal the container tightly for any remaining material.

Safety and Handling

• General handling: Handle in a well-ventilated area or chemical fume hood. Avoid unnecessary exposure and follow standard laboratory practices for handling organic compounds.

• Personal protection: Wear suitable protective gloves, safety glasses or goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before use, storage, or transportation to ensure appropriate precautions are observed.