Amino-PEG8-alcohol

Amino-PEG8-alcohol (CAS 352439-37-3), also known as NH2-PEG8-OH, is a monodisperse bifunctional polyethylene glycol derivative featuring a terminal primary amine and a terminal hydroxyl group connected by an octaethylene glycol spacer. This structure makes it a valuable molecular linker intermediate for organic synthesis and bioconjugation applications.

Basic Information

CAS No.	352439-37-3
EC No.	Not available
Linear Formula	H₂N-(CH₂CH₂O)₈-H
Molecular Weight	369.45 g/mol
Appearance	Colorless to light yellow viscous liquid or solid
Melting Point	Not available (typical reference)
Boiling point	464.4 ± 40.0 °C (Predicted)
Density	Approximately 1.09 g/cm³ (typical reference)
Solubility	Soluble in water and polar organic solvents such as DMSO and DMF
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage at -20°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Provides a defined eight-unit PEG spacer with amino and hydroxyl end groups for the assembly of PROTAC molecules and non-cleavable ADC linkers.

• Bioconjugation research: The primary amine enables efficient coupling to carboxylic acids and activated esters, while the hydroxyl group allows further derivatization of biomolecules.

• Fine chemical intermediate: Serves as a versatile building block for introducing hydrophilic polyether chains into complex organic molecules during specialty synthesis.

• Process development: Supports laboratory and pilot-scale efforts in optimizing synthetic routes that incorporate precise PEG-based linkers with controlled spacer lengths.

• Laboratory research: Commonly used in medicinal chemistry laboratories for exploring PEGylation strategies and developing functional conjugates with tailored hydrophilic properties.

• Consistent product quality: High-purity Amino-PEG8-alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Available in small laboratory quantities in sealed containers or sample bottles; larger volumes supplied in suitable HDPE drums. Customized liquid packaging options can be arranged based on specific requirements.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated place. Protect from moisture. Long-term storage recommended at -20°C.

• Handling of opened containers: After opening, minimize exposure to air and moisture. Use the contents promptly and reseal the container tightly to maintain product integrity.

Safety and Handling

• General handling: Work in a well-ventilated area or chemical fume hood. Follow standard laboratory practices for handling organic compounds with amine and alcohol functional groups.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before handling, storage, or transportation to ensure appropriate precautions are observed.