1-Benzylpiperazine

1-Benzylpiperazine is an N-benzyl-substituted piperazine derivative used as an organic intermediate in selected pharmaceutical intermediate, fine chemical, and specialty synthesis routes. Its structure contains a piperazine ring with one benzyl-substituted nitrogen and one secondary amine site, providing functional group compatibility for further derivatization.

Basic Information

CAS No.	2759-28-6
EC No.	220-423-6
Linear Formula	C11H16N2
Molecular Weight	176.26
Appearance	Colorless to light yellow liquid or low-melting solid
Melting Point	20-24 °C (lit.)
Boiling point	146 °C at 10 mmHg (lit.)
Density	1.02 g/mL at 25 °C (lit.)
Solubility	Soluble in organic solvents; slightly soluble in water
Storage Conditions	Keep in a cool, dry place, protected from light and moisture, under inert atmosphere if necessary
Chemical Structure

Key Applications

• Pharmaceutical intermediate: Used as an N-substituted piperazine intermediate in selected pharmaceutical intermediate synthesis routes, depending on the target structure and regulatory requirements.

• Organic synthesis intermediate: Can support further functionalization of the piperazine ring through the remaining secondary amine site.

• Heterocyclic synthesis: May be evaluated in route development involving piperazine-containing nitrogen heterocyclic intermediates.

• Research and route development: Suitable for exploratory synthesis, route screening, and intermediate evaluation involving benzylpiperazine structures, subject to applicable controls.

• Specialty synthesis applications: May support process evaluation for fine chemical and specialty intermediate projects where N-benzyl piperazine functionality is required.

Related Heterocycle Intermediates

Buyers sourcing aryl, benzyl, or N-substituted piperazine derivatives may also review related piperazine intermediates such as 1-Phenylpiperazine CAS 92-54-6, 1-(2,3-Dichlorophenyl)piperazine CAS 41202-77-1, and 1-(2-Pyridyl)piperazine CAS 34803-66-2.

For related hydroxyethyl or chloroalkyl piperazine intermediates, buyers may also compare 1-(2-Hydroxyethyl)piperazine CAS 103-76-4, 1-(2-Hydroxyethyl)-4-methylpiperazine CAS 5464-12-0, and 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride CAS 2031-23-4.

• Sourcing feasibility review: Availability, lead time, and order quantity are confirmed according to the specific product, supplier batch, current market conditions, and destination requirements.

• SDS and COA support: Available safety data sheets and certificates of analysis can be provided upon request, subject to the specific supplier, batch, and grade.

• Regulatory and export review: Applicable controls, import restrictions, documentation needs, and shipment feasibility should be reviewed according to the product, destination market, and intended use.

• Packaging and export coordination: Packaging format, labeling, documentation, and shipping terms can be discussed according to product properties, order quantity, and destination requirements.