1-Phenylpiperazine

1-Phenylpiperazine is an N-aryl piperazine derivative used as an organic intermediate in selected pharmaceutical intermediate, fine chemical, and specialty synthesis routes. Its structure contains a piperazine ring with one phenyl-substituted nitrogen and one secondary amine site, providing useful functionality for further derivatization.

Basic Information

CAS No.	92-54-6
EC No.	202-165-6
Linear Formula	C10H14N2
Molecular Weight	162.23
Appearance	Colorless to light yellow liquid or low-melting solid
Melting Point	18-20 °C (lit.)
Boiling point	286 °C (lit.)
Density	1.062 g/mL at 25 °C (lit.)
Solubility	Slightly soluble in water; soluble in ethanol, ether, and chloroform
Storage Conditions	Keep in a cool, dry place, protected from light and moisture, under inert atmosphere
Chemical Structure

Key Applications

• Pharmaceutical intermediate: Used as an N-aryl piperazine intermediate in selected pharmaceutical intermediate synthesis routes, depending on the target structure and specification requirements.

• Organic synthesis intermediate: Can support alkylation, acylation, and other derivatization reactions through the remaining secondary amine site.

• Heterocyclic synthesis: May be evaluated in route development involving piperazine-containing nitrogen heterocyclic intermediates.

• Research and route development: Suitable for exploratory synthesis, route screening, and intermediate evaluation involving phenylpiperazine structures.

• Specialty synthesis applications: May support process evaluation for fine chemical and specialty intermediate projects where N-aryl piperazine functionality is required.

Related Heterocycle Intermediates

Buyers sourcing aryl, benzyl, or N-substituted piperazine derivatives may also review related piperazine intermediates such as 1-Benzylpiperazine CAS 2759-28-6, 1-(2,3-Dichlorophenyl)piperazine CAS 41202-77-1, and 1-(2-Pyridyl)piperazine CAS 34803-66-2.

• Sourcing feasibility review: Availability, lead time, and order quantity are confirmed according to the specific product, supplier batch, current market conditions, and destination requirements.

• SDS and COA support: Available safety data sheets and certificates of analysis can be provided upon request, subject to the specific supplier, batch, and grade.

• Regulatory and export review: Applicable controls, import restrictions, documentation needs, and shipment feasibility should be reviewed according to the product, destination market, and intended use.

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