1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride

1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride is a chloroalkyl-substituted N-methyl piperazine derivative supplied in dihydrochloride salt form. It is used as an organic intermediate in selected pharmaceutical intermediate, fine chemical, and specialty synthesis routes. Its structure combines a 4-methylpiperazine core with a chloropropyl side chain, providing chloroalkyl functionality for downstream substitution or further transformation.

Basic Information

CAS No.	2031-23-4
EC No.	217-981-8
Linear Formula	C8H19Cl3N2
Molecular Weight	249.61
Appearance	White to off-white powder or crystals
Melting Point	255-257 °C (decomp.) (lit.)
Boiling point	Not available (typical reference)
Density	Not available (typical reference)
Solubility	Soluble in DMSO and methanol
Storage Conditions	Under inert gas, store at 2-8°C, protected from moisture
Chemical Structure

Key Applications

• Organic synthesis intermediate: Can be used as a chloropropyl methylpiperazine intermediate in selected organic synthesis routes involving nucleophilic substitution or further functionalization.

• Pharmaceutical intermediate: Used as a piperazine-based intermediate in selected pharmaceutical intermediate synthesis routes, depending on the target structure, salt form, and specification requirements.

• Fine chemical synthesis: May be evaluated in the preparation of functionalized piperazine derivatives and specialty nitrogen heterocycle intermediates.

• Research and route development: Suitable for exploratory synthesis, route screening, and intermediate evaluation involving chloroalkyl or N-methyl piperazine structures.

• Specialty synthesis applications: May support process evaluation for fine chemical and specialty intermediate projects where chloropropyl piperazine functionality is required.

Related Heterocycle Intermediates

Buyers sourcing chloroalkyl, hydroxyethyl, or N-methyl piperazine derivatives may also review related piperazine intermediates such as 1-(3-Chloropropyl)-4-(2-hydroxyethyl)piperazine CAS 57227-28-8, 1-(2-Hydroxyethyl)-4-methylpiperazine CAS 5464-12-0, and 4-Methyl-1-piperazinepropanol CAS 5317-33-9.

For related chloroalkyl nitrogen heterocycles outside the piperazine series, buyers may also compare 4-(3-Chloropropyl)morpholine CAS 7357-67-7, 4-(2-Chloroethyl)morpholine hydrochloride CAS 3647-69-6, and 1-(3-Chloropropyl)piperidin-4-ol CAS 145285-36-5.

• Sourcing feasibility review: Availability, lead time, and order quantity are confirmed according to the specific product, supplier batch, current market conditions, and destination requirements.

• SDS and COA support: Available safety data sheets and certificates of analysis can be provided upon request, subject to the specific supplier, batch, and grade.

• Documentation and export review: Documentation needs, import requirements, and shipment feasibility should be reviewed according to the product, destination market, and intended use.

• Packaging and export coordination: Packaging format, labeling, documentation, and shipping terms can be discussed according to product properties, order quantity, and destination requirements.