Pentaethylene glycol

Its terminal hydroxyl functionality supports further derivatization, making it a valuable building block for constructing PEGylated intermediates in pharmaceutical and specialty chemical development.

Basic Information

CAS No.	4792-15-8
EC No.	225-341-4
Linear Formula	HO(CH2CH2O)5H
Molecular Weight	238.28 g/mol
Appearance	Clear colorless to slightly yellow liquid
Melting Point	-8.6 °C (lit.)
Boiling point	184 °C / 2 mmHg (lit.)
Density	1.126 g/mL at 25 °C (lit.)
Solubility	Miscible with water; soluble in polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage under inert atmosphere.
Chemical Structure

Key Applications

• PEG linker intermediate: The short, well-defined five-unit polyether chain with hydroxyl end groups provides a hydrophilic spacer ideal for linker construction in bioconjugation and PEGylation research.

• Molecular linker intermediate: Serves as a flexible linker for connecting functional moieties in the assembly of complex organic molecules and advanced intermediates.

• Fine chemical intermediate: Used in the synthesis of specialty chemicals where the polyether backbone imparts specific solubility and flexibility characteristics.

• Laboratory research: Commonly applied in medicinal chemistry laboratories for exploring PEG-modified compounds and their properties.

• Process development: Supports the development and optimization of synthetic routes involving PEG spacers for scale-up in fine chemical production.

• Consistent product quality: Offered at 98% purity with consistent quality attributes suitable for demanding fine chemical applications.

• Flexible global supply: Supports international customers with reliable export arrangements from sample quantities to bulk volumes.

• SDS and COA support: Product documentation is provided to meet the needs of export, quality review and regulatory processes.

• Packaging and technical service: Flexible options for packaging and professional technical assistance for product selection and application inquiries.

Packaging and Storage

• Packaging: Available in 1 kg and 5 kg sample bottles as well as 25 L and 200 L HDPE drums for larger orders. Customized liquid packaging can be arranged upon request.

• Storage: Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials.

• Handling of opened containers: Reseal containers tightly after use and store under recommended conditions to maintain product integrity.

• Bulk supply: Suitable packaging and lead times available for pilot-scale and commercial bulk requirements.

Safety and Handling

• General handling: Handle according to good laboratory and industrial hygiene practices. Avoid unnecessary exposure and contact with skin or eyes.

• Personal protection: Use appropriate personal protective equipment including gloves, safety goggles and protective clothing during handling.

• Documentation review: Review the current Safety Data Sheet (SDS) before use, storage or transportation of the material.

• Compatibility: Incompatible with strong oxidizing agents, acid chlorides and acid anhydrides. Conduct compatibility assessment prior to mixing with other substances.