Nonaethylene Glycol

Nonaethylene glycol, commonly known as PEG-9 or HO-PEG9-OH, is a monodisperse polyethylene glycol derivative featuring nine ethylene oxide units with terminal hydroxyl groups. It is a key hydrophilic building block widely employed in the synthesis of molecular linkers and functional PEG derivatives for advanced chemical applications.

Basic Information

CAS No.	3386-18-3
EC No.	222-206-1
Linear Formula	HO(CH2CH2O)9H
Molecular Weight	414.49 g/mol
Appearance	White to almost white powder to lump
Melting Point	24–26 °C (lit.)
Boiling point	Not available (typical reference)
Density	1.115 g/cm³ (predicted)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture. Recommended storage below 15 °C.
Chemical Structure

Key Applications

• PEG linker intermediate: Nonaethylene glycol functions as a well-defined hydrophilic linker in bioconjugation and PEGylation strategies, providing precise spacer length for pharmaceutical intermediate development and targeted delivery research.

• Hydrophilic spacer: The nine-unit PEG chain serves as an effective hydrophilic spacer, enhancing water solubility and biocompatibility when incorporated into complex molecular architectures during fine chemical synthesis.

• Fine chemical intermediate: Acts as a versatile diol building block for introducing polyether segments and enabling further functionalization through its reactive terminal hydroxyl groups in organic synthesis projects.

• Laboratory research: Extensively used in academic and industrial research laboratories for exploring PEG-based linkers, surface modifications, and the development of novel specialty chemicals.

• Process development: Supports route optimization, scale-up studies, and custom synthesis of PEG-containing advanced intermediates for pharmaceutical and specialty chemical applications.

• Consistent product quality: High-purity material (95%+) with reliable batch consistency, supported by thorough quality coordination suitable for demanding fine chemical and research applications.

• Flexible global supply: Established supply chain and logistics support enabling timely delivery for laboratory-scale, pilot-scale, and bulk orders to customers worldwide.

• SDS and COA support: Full documentation package including SDS and COA provided upon request to assist with regulatory compliance, export procedures, and internal quality assessments.

• Packaging and technical service: Customized packaging solutions based on quantity requirements along with responsive technical communication to address specific sourcing and application needs.

Packaging and Storage

• Packaging: Supplied in 1 kg, 5 kg, or 25 kg quantities; bulk orders available in fiber drums with protective inner liners or other customized packaging configurations upon request.

• Storage: Store in tightly sealed containers in a cool, dry, and well-ventilated environment. Protect from moisture and direct sunlight; recommended storage temperature below 15 °C to maintain stability.

• Handling of opened containers: Immediately reseal opened containers after dispensing and return to recommended storage conditions. Minimize exposure to air and moisture during handling operations.

Safety and Handling

• General handling: Use in well-ventilated areas following standard laboratory or industrial safety protocols. Avoid ingestion, inhalation, and direct contact with skin or eyes.

• Personal protection: Wear chemical-resistant gloves, safety goggles or face shield, and suitable protective clothing. Respiratory protection may be necessary if aerosol or dust formation occurs.

• Documentation review: Consult the current Safety Data Sheet (SDS) for detailed information on safe handling, storage, transportation, and disposal before use.