1,1,2-Trimethoxyethane

1,1,2-Trimethoxyethane (CAS 24332-20-5) is a stable acetal that serves as a protected form of methoxyacetaldehyde in organic synthesis. It allows controlled release of the reactive aldehyde functionality under acidic conditions while remaining stable during handling and storage.

Basic Information

CAS No.	24332-20-5
EC No.	Not available
Linear Formula	C5H12O3
Molecular Weight	120.15
Appearance	Colorless to almost colorless clear liquid
Melting Point	Not available (typical reference)
Boiling point	126 °C (lit.)
Density	0.932 g/mL at 25 °C (lit.)
Solubility	Soluble in common organic solvents
Storage Conditions	Store in a tightly closed container in a cool, dry place. Keep away from heat and ignition sources.
Chemical Structure

Key Applications

• Protected aldehyde intermediate: 1,1,2-Trimethoxyethane functions as a stable acetal-protected form of methoxyacetaldehyde, enabling controlled introduction of aldehyde functionality in multi-step organic synthesis. It is widely used in Acetals and Protected Carbonyl Ethers for Organic Synthesis, where masked carbonyl groups improve reaction selectivity and stability.

• Acetal chemistry and protection strategies: This compound is applied in protecting group chemistry, allowing reversible masking of aldehyde functionality during complex transformations. Such applications are part of the acetal and protected carbonyl ether application category.

• Fine chemical intermediate: Employed in the synthesis of specialty chemicals and pharmaceutical intermediates requiring controlled release of aldehyde functionality under defined reaction conditions.

• Functional molecule construction: Facilitates the assembly of complex molecules through acetal-based strategies, supporting the design of advanced intermediates with improved stability and reactivity control.

• Laboratory research: Widely used in research for synthetic methodology development, particularly in acetal chemistry, carbonyl protection strategies, and stepwise functional group transformations.

• Process development: Supports route optimization and scale-up in processes requiring stable acetal intermediates and controlled deprotection steps in organic synthesis.

1,1,2-Trimethoxyethane belongs to the Acetals and Protected Carbonyl Ethers application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering acetal derivatives, protected aldehydes, and ether-based intermediates for API and fine chemical synthesis.

• Flexible global supply: Established logistics networks ensure stable international supply from laboratory to bulk scale for fine chemical customers worldwide.

• SDS and COA support: Complete SDS, COA, and technical documentation available upon request to facilitate quality review and international procurement.

• Packaging and technical service: Flexible packaging in 25L/200L HDPE drum, backed by responsive technical assistance for application support.