Tetraethylene Glycol Monobenzyl Ether

Tetraethylene Glycol Monobenzyl Ether (CAS 86259-87-2), also referred to as Bn-PEG4-OH or Ph-PEG4-OH, is a discrete polyethylene glycol derivative consisting of a benzyl-protected chain with a terminal hydroxyl group. This compound functions as a hydrophilic molecular linker and spacer in organic synthesis, offering four ethylene oxide units for controlled chain extension and functionalization.

Basic Information

CAS No.	86259-87-2
EC No.	Not available
Linear Formula	C15H24O5
Molecular Weight	284.35 g/mol
Appearance	White to yellow to green clear liquid
Melting Point	Not available (typical reference)
Boiling point	170–174 °C at 25 Torr (lit.)
Density	1.10 g/mL at 20 °C (lit.)
Solubility	Soluble in chloroform, DMSO, and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and light. Recommended storage temperature below 15°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Serves as a hydrophilic tetraethylene glycol spacer and benzyl-protected building block for constructing functional linkers in bioconjugation and drug delivery research.

• Molecular linker intermediate: Enables precise incorporation of PEG4 units into complex organic molecules during functional molecule construction and advanced intermediate synthesis.

• Hydrophilic spacer: Provides a flexible, water-compatible spacer arm for improving solubility and spatial orientation in specialty chemical and research compound design.

• Fine chemical intermediate: Used in the preparation of PEGylated specialty chemicals and pharmaceutical intermediates requiring controlled polyether chain length.

• Laboratory research: Applied in medicinal chemistry, synthetic methodology studies, and process development involving benzyl-protected PEG derivatives with terminal hydroxy functionality.

• Consistent product quality: High-purity grade exceeding 95% by GC with reliable batch-to-batch consistency suitable for fine chemical synthesis and research applications.

• Flexible global supply: Support for laboratory-scale samples, pilot quantities, and bulk orders through established international logistics and export channels.

• SDS and COA support: Complete documentation including Safety Data Sheets and Certificates of Analysis provided to assist quality review, regulatory compliance, and procurement processes.

• Packaging and technical service: Customized liquid packaging options together with responsive technical communication for sourcing specifications and order coordination.

Packaging and Storage

• Packaging: Available in small laboratory quantities (1 g, 5 g, 25 g bottles) and larger liquid containers such as HDPE drums. Customized packaging configurations provided upon request for specific volumes.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Recommended storage temperature is room temperature or below 15°C, protected from moisture and light exposure.

• Handling of opened containers: Minimize air and moisture exposure after opening. Reseal containers immediately and use contents promptly to preserve product quality.

• Bulk supply: Flexible arrangements available for pilot-scale and commercial bulk procurement with appropriate drum or container packaging suited to liquid form.

Safety and Handling

• General handling: Handle in accordance with standard laboratory and industrial hygiene practices. Avoid inhalation, ingestion, and direct contact with skin or eyes.

• Personal protection: Wear appropriate protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation during handling.

• Documentation review: Always review the latest Safety Data Sheet (SDS) prior to handling, storage, transportation, or use of the product.

• Compatibility: Incompatible with strong oxidizing agents, strong acids, and strong bases. Conduct compatibility assessment before combining with other materials.