Pentaethylene Glycol Monobenzyl Ether

Pentaethylene Glycol Monobenzyl Ether, commonly known as Bn-PEG5-OH or Ph-PEG5-OH (CAS 57671-28-0), is a discrete polyethylene glycol derivative featuring five ethylene oxide units, a benzyl protecting group at one end, and a free terminal hydroxyl group. This structure provides a well-defined hydrophilic spacer suitable for precise molecular construction in fine chemical and research applications.

Basic Information

CAS No.	57671-28-0
EC No.	Not available
Linear Formula	C17H28O6
Molecular Weight	328.41 g/mol
Appearance	White to yellow to green clear liquid
Melting Point	Not available (typical reference)
Boiling point	Not available (typical reference)
Density	1.10 g/mL at 20 °C (lit.)
Solubility	Soluble in DMSO, DCM, DMF and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and light. Recommended storage temperature below 15°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Functions as a defined hydrophilic pentaethylene glycol spacer for constructing functional linkers in bioconjugation and drug delivery research.

• Molecular linker intermediate: Enables controlled incorporation of PEG5 units into complex organic structures during functional molecule construction and advanced synthesis.

• Hydrophilic spacer: Provides extended hydrophilic character to enhance solubility and spatial properties in specialty chemical and research compound design.

• Fine chemical intermediate: Used in the preparation of PEGylated specialty materials and pharmaceutical intermediates requiring precise polyether chain length.

• Laboratory research: Applied in medicinal chemistry studies and custom synthesis projects involving benzyl-protected PEG5 derivatives with reactive terminal hydroxy group.

• Consistent product quality: High-purity specifications exceeding 95% by GC with reliable batch consistency suitable for demanding research and fine chemical applications.

• Flexible global supply: Support for laboratory samples, pilot-scale quantities, and bulk orders through established export logistics and international channels.

• SDS and COA support: Full documentation package including Safety Data Sheets and Certificates of Analysis provided to meet quality review and procurement requirements.

• Packaging and technical service: Customized liquid packaging options together with responsive technical communication for sourcing specifications and order coordination.

Packaging and Storage

• Packaging: Supplied in small laboratory quantities such as 1 g and 5 g bottles with options for larger liquid containers including HDPE drums. Customized packaging available upon request for specific volumes and requirements.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Recommended storage temperature is room temperature or below 15°C, protected from moisture and light.

• Handling of opened containers: Minimize exposure to air and moisture after opening. Reseal containers tightly and use contents promptly to maintain product integrity.

• Bulk supply: Flexible arrangements supported for pilot and commercial bulk procurement with suitable liquid packaging configurations matched to order quantity.

Safety and Handling

• General handling: Handle according to good laboratory and industrial hygiene practices. Avoid inhalation, ingestion, and direct contact with skin or eyes.

• Personal protection: Wear suitable protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation in the work area.

• Documentation review: Consult the latest Safety Data Sheet (SDS) before handling, storage, transportation, or use of the product.

• Compatibility: Incompatible with strong oxidizing agents, strong acids, and strong bases. Perform compatibility assessment prior to use with other materials.