2-(2-(2-benzyloxyethoxy)ethoxy)ethanol

2-(2-(2-Benzyloxyethoxy)ethoxy)ethanol, also known as triethylene glycol monobenzyl ether or BnO-PEG3-OH, is a clear liquid specialty chemical featuring a benzyl-protected hydroxy group attached to a triethylene glycol chain. This structure provides a hydrophilic spacer of defined length, useful for constructing functional PEG linkers in molecular design.

Basic Information

CAS No.	55489-58-2
EC No.	Not available
Linear Formula	C6H5CH2O(CH2CH2O)3H
Molecular Weight	240.30 g/mol
Appearance	Colorless to light yellow to light orange clear liquid
Melting Point	Not available (typical reference)
Boiling point	131 °C (lit.)
Density	1.09 g/mL at 20 °C (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from light. Recommended storage at room temperature or below 15°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Serves as a defined-length hydrophilic PEG3 spacer with benzyl-protected terminal hydroxy group for linker construction in bioconjugation, ADC, and PROTAC research.

• Organic synthesis intermediate: Acts as a building block for incorporating triethylene glycol units into complex organic molecules and functional materials through ether or ester bond formation.

• Pharmaceutical intermediate: Used in medicinal chemistry research to introduce hydrophilic segments that can improve solubility or pharmacokinetic properties of drug candidates.

• Laboratory research: Commonly employed in academic and industrial laboratories for developing new synthetic methodologies involving protected PEG derivatives and spacer optimization.

• Process development: Supports route optimization and custom synthesis projects requiring high-purity specialty PEG intermediates for scalable production of advanced molecules.

• Consistent product quality: High-purity grades with reliable batch consistency maintained through quality coordination, suitable for demanding applications in fine chemical synthesis and research.

• Flexible global supply: Stable export capabilities via established logistics channels, supporting orders from laboratory-scale samples to pilot and bulk quantities for international customers.

• SDS and COA support: Full documentation package including Safety Data Sheets and Certificates of Analysis available upon request to assist with compliance, quality assessment, and export procedures.

• Packaging and technical service: Professional technical communication and assistance with appropriate liquid packaging selection based on order size, product form, and customer handling requirements.

Packaging and Storage

• Packaging: Supplied in laboratory quantities such as 1 kg or 5 kg sample bottles and larger commercial packs in 25 L or 200 L HDPE drums. Customized liquid packaging options are available upon request to match specific volume and handling preferences.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated environment. Protection from light is recommended, with ideal conditions at room temperature or below 15°C as per supplier guidelines.

• Handling of opened containers: Reseal containers immediately after opening and maintain recommended storage conditions to preserve product integrity. Apply standard liquid chemical handling protocols during use or transfer.

Safety and Handling

• General handling: Use in well-ventilated areas and avoid direct skin or eye contact as well as inhalation of vapors. Follow good industrial hygiene and safety practices for handling liquid reagents.

• Personal protection: Wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Refer to the product SDS for detailed PPE recommendations.

• Documentation review: Review the most current Safety Data Sheet (SDS) and supporting documents prior to handling, storage, transportation, or use to ensure safe practices and regulatory compliance.