Hexaethylene Glycol Monobenzyl Ether

Hexaethylene Glycol Monobenzyl Ether, also known as BnO-PEG6-OH or Ph-PEG6-OH (CAS 24342-68-5), is a discrete polyethylene glycol derivative comprising six ethylene oxide units with a benzyl protecting group and a terminal hydroxyl functionality. This well-defined structure serves as an extended hydrophilic spacer in molecular linker design for fine chemical and research applications.

Basic Information

CAS No.	24342-68-5
EC No.	Not available
Linear Formula	C19H32O7
Molecular Weight	372.46 g/mol
Appearance	Colorless to light yellow clear liquid
Melting Point	Not available (typical reference)
Boiling point	Not available (typical reference)
Density	1.10 g/mL at 20 °C (lit.)
Solubility	Soluble in DMSO, DCM, DMF and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and light. Recommended storage temperature below 15°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Provides an extended hydrophilic hexaethylene glycol spacer for constructing functional linkers in bioconjugation and advanced drug delivery research.

• Molecular linker intermediate: Enables precise incorporation of PEG6 units into complex organic molecules during functional molecule construction and specialty synthesis.

• Hydrophilic spacer: Delivers longer hydrophilic character to enhance solubility, flexibility, and spatial properties in research compound design.

• Fine chemical intermediate: Used in the preparation of PEGylated specialty materials and pharmaceutical intermediates requiring defined polyether chain length.

• Laboratory research: Applied in medicinal chemistry studies, process development, and custom synthesis projects involving benzyl-protected PEG6 derivatives with reactive terminal hydroxy group.

• Consistent product quality: High-purity grade with reliable batch-to-batch consistency suitable for fine chemical synthesis and demanding research applications.

• Flexible global supply: Support for laboratory samples, pilot-scale quantities, and bulk orders through established international logistics and export channels.

• SDS and COA support: Comprehensive documentation including Safety Data Sheets and Certificates of Analysis provided to assist quality review and regulatory processes.

• Packaging and technical service: Customized liquid packaging solutions together with responsive technical communication for sourcing specifications and order requirements.

Packaging and Storage

• Packaging: Available in small laboratory quantities such as 1 g bottles with options for larger liquid containers including HDPE drums. Customized packaging configurations provided upon request for specific volumes.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Recommended storage temperature is room temperature or below 15°C, protected from moisture and light.

• Handling of opened containers: Minimize air and moisture exposure after opening. Reseal containers immediately and use contents promptly to preserve product quality.

• Bulk supply: Flexible arrangements supported for pilot-scale and commercial bulk procurement with suitable liquid packaging matched to order quantity and viscosity.

Safety and Handling

• General handling: Handle in accordance with good laboratory and industrial hygiene practices. Avoid inhalation, ingestion, and direct contact with skin or eyes.

• Personal protection: Wear suitable protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation during use.

• Documentation review: Always review the latest Safety Data Sheet (SDS) prior to handling, storage, transportation, or use of the product.

• Compatibility: Incompatible with strong oxidizing agents, strong acids, and strong bases. Conduct compatibility assessment before combining with other materials.