Bis[2-(2-chloroethoxy)ethyl] Ether

Bis[2-(2-chloroethoxy)ethyl] ether (CAS 638-56-2), also known as tetraethylene glycol dichloride or 1,11-dichloro-3,6,9-trioxaundecane, is a bifunctional dichloro-terminated polyether derivative featuring two reactive chloroethyl end groups connected by a triethylene glycol chain. This structure makes it a versatile building block for nucleophilic substitution reactions in fine chemical synthesis.

Basic Information

CAS No.	638-56-2
EC No.	Not available
Linear Formula	C8H16Cl2O3
Molecular Weight	231.12 g/mol
Appearance	Colorless to yellow to green clear liquid
Melting Point	Not available (typical reference)
Boiling point	139 °C at 3 mmHg (lit.)
Density	1.18 g/mL at 20 °C (lit.)
Solubility	Soluble in chloroform and dichloromethane; slightly soluble in ethyl acetate, methanol, and water
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials. Store at room temperature.
Chemical Structure

Key Applications

• Organic synthesis intermediate: Serves as a bifunctional building block for introducing PEG chains through nucleophilic substitution of the terminal chloro groups in fine chemical and specialty synthesis.

• Molecular linker intermediate: Functions as a precursor for symmetric PEG-based linkers and spacers in the construction of functional molecules and advanced intermediates.

• Fine chemical intermediate: Employed in the preparation of PEGylated specialty compounds and derivatives for pharmaceutical and research applications requiring dichloro-terminated polyethers.

• Laboratory research: Applied in medicinal chemistry studies and synthetic methodology development involving reactive chloroethyl PEG derivatives for further functionalization.

• Custom synthesis: Supports route optimization and custom projects requiring dichloro PEG intermediates for the development of novel PEGylated structures and process intermediates.

• Consistent product quality: High-purity specifications with reliable batch consistency suitable for demanding organic synthesis and fine chemical applications.

• Flexible global supply: Support for laboratory-scale samples, pilot quantities, and bulk orders through established international logistics and export channels.

• SDS and COA support: Comprehensive documentation including Safety Data Sheets and Certificates of Analysis provided to meet quality review and procurement requirements.

• Packaging and technical service: Customized liquid packaging options together with responsive technical communication for sourcing specifications and order coordination.

Packaging and Storage

• Packaging: Supplied in small laboratory quantities and larger liquid containers such as HDPE drums. Customized packaging configurations available upon request for specific volumes and requirements.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Recommended storage temperature is room temperature, protected from moisture and light.

• Handling of opened containers: Minimize exposure to air and moisture after opening. Reseal containers tightly and use contents promptly to maintain product integrity.

• Bulk supply: Flexible arrangements supported for pilot-scale and commercial bulk procurement with suitable liquid packaging matched to order quantity.

Safety and Handling

• General handling: Handle in accordance with good laboratory and industrial hygiene practices. Avoid inhalation, ingestion, and direct contact with skin or eyes.

• Personal protection: Wear suitable protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation in the work area.

• Documentation review: Always review the latest Safety Data Sheet (SDS) prior to handling, storage, transportation, or use of the product.

• Compatibility: Incompatible with strong oxidizing agents, strong bases, and strong nucleophiles. Conduct compatibility assessment before combining with other materials.