1,8-Diamino-3,6-dioxaoctane

The terminal amino groups enable straightforward coupling reactions such as amide bond formation, while the PEG3 chain imparts hydrophilicity and conformational flexibility. It is commonly handled as a liquid and finds use in laboratory-scale research through to pilot and bulk process development. Product specifications typically range from 95% to 99%+ purity depending on grade requirements.

Basic Information

CAS No.	929-59-9
EC No.	213-206-7
Linear Formula	H₂N(CH₂CH₂O)₂CH₂CH₂NH₂
Molecular Weight	148.20 g/mol
Appearance	Colorless to pale yellow liquid
Melting Point	Not available (typical reference)
Boiling point	120 °C at 2 mmHg (lit.)
Density	~1.0 g/mL at 20 °C (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials.
Chemical Structure

Key Applications

• PEG linker intermediate: The short PEG3 chain with terminal amino groups serves as a hydrophilic spacer for constructing PEGylated molecules and bioconjugates in pharmaceutical research.

• Molecular linker intermediate: Functions as a flexible building block for linking functional moieties through amide or other coupling reactions in organic synthesis.

• Bioconjugation research: Enables efficient attachment of biomolecules or labels via its primary amino end groups in medicinal chemistry and surface modification studies.

• Fine chemical intermediate: Applied in the preparation of advanced intermediates where a short, water-soluble diamine spacer is required for molecular design.

• Process development: Supports route scouting, optimization, and scale-up work for custom synthesis projects involving PEG-based functional materials.

• Consistent product quality: High-purity material with reliable batch consistency suitable for fine chemical synthesis and research applications.

• Flexible global supply: Support for laboratory, pilot-scale, and bulk quantities through established international logistics and export channels.

• SDS and COA support: Product documentation including SDS and COA is available to assist with quality review, regulatory compliance, and procurement processes.

• Packaging and technical service: Responsive communication and assistance with packaging selection based on order size and product handling requirements.

Packaging and Storage

• Packaging: Available in small quantity sample bottles, 1 L to 25 L HDPE drums, and larger bulk containers depending on customer requirements.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area away from moisture and incompatible substances.

• Handling of opened containers: Minimize exposure to air and moisture after opening; use contents promptly and reseal containers carefully.

• Bulk supply: Flexible packaging and delivery arrangements available for pilot and commercial-scale orders.

Safety and Handling

• General handling: Handle under conditions of good industrial hygiene. Avoid unnecessary contact with skin, eyes, and clothing during transfer and processing.

• Personal protection: Use appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and protective clothing as needed.

• Documentation review: Always consult the latest Safety Data Sheet before handling, storage, transportation, or use of the material.

• Compatibility: Review compatibility with process materials and avoid contact with strong oxidizing agents or conditions that may affect amine functionality.