2-[2-(Benzyloxy)ethoxy]ethanol

2-[2-(Benzyloxy)ethoxy]ethanol, commonly known as diethylene glycol monobenzyl ether or BnO-PEG2-OH, is a clear liquid fine chemical that serves as a protected hydrophilic building block. Its structure combines a benzyl-protected hydroxy group with a short diethylene glycol chain, making it suitable for constructing functional linkers in molecular synthesis.

Basic Information

CAS No.	2050-25-1
EC No.	Not available
Linear Formula	C6H5CH2O(CH2CH2O)2H
Molecular Weight	196.24 g/mol
Appearance	Colorless to light yellow clear liquid
Melting Point	Not available (typical reference)
Boiling point	80-110 °C at 0.5 mm Hg (lit.)
Density	1.094 g/mL at 25 °C (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from light. Store at room temperature.
Chemical Structure

Key Applications

• PEG linker intermediate: Utilized in the design of short hydrophilic spacers for bioconjugation, PROTAC linkers, and molecular probe construction where a protected diethylene glycol unit is required.

• Organic synthesis intermediate: Serves as a versatile building block for introducing ether-linked hydrophilic segments and protected hydroxyethyl chains in multi-step organic syntheses.

• Pharmaceutical intermediate: Employed in medicinal chemistry research for developing drug candidates and advanced intermediates that incorporate PEG-like moieties for improved solubility or targeting.

• Laboratory research: Widely used in academic and industrial laboratories to explore new synthetic methodologies involving protected PEG derivatives and functional group transformations.

• Process development: Supports route optimization and custom synthesis projects requiring high-purity specialty reagents for scalable production of complex molecules.

• Consistent product quality: High-purity grades maintained through routine quality coordination, ensuring batch-to-batch consistency suitable for fine chemical synthesis and research applications.

• Flexible global supply: Stable export arrangements supported by established logistics channels, enabling reliable delivery for laboratory, pilot-scale, and bulk procurement needs worldwide.

• SDS and COA support: Comprehensive documentation including Safety Data Sheets and Certificates of Analysis provided upon request to support regulatory compliance and quality review for international sourcing.

• Packaging and technical service: Responsive technical communication and assistance with selecting suitable liquid packaging options tailored to sample, trial, or bulk order requirements.

Packaging and Storage

• Packaging: Available in small laboratory quantities such as 1 kg or 5 kg sample bottles, as well as larger packs in 25 L or 200 L HDPE drums. Customized liquid packaging can be arranged based on specific order size and handling needs.

• Storage: Store in tightly closed containers in a cool, dry, and well-ventilated area. Protection from light is recommended, with storage at room temperature under sealed and dry conditions.

• Handling of opened containers: Promptly reseal opened containers and return them to the recommended storage conditions to maintain product quality. Use standard precautions for handling liquid chemicals during transfer or processing.

Safety and Handling

• General handling: Handle in well-ventilated areas and avoid direct contact with skin or eyes as well as inhalation of vapors. Follow established good industrial hygiene and safety practices for liquid reagents.

• Personal protection: Wear suitable protective equipment including chemical-resistant gloves, safety goggles, and appropriate clothing. Consult the latest SDS for specific personal protection recommendations.

• Documentation review: Always review the current Safety Data Sheet (SDS) and supporting product documents before handling, storage, transportation, or use to ensure safe practices and compliance.