N-Methylpiperidine

Basic Information of N-Methylpiperidine

CAS No.:	626-67-5
EC No.:	210-959-9
Linear Formula:	CH₃–N–(CH₂)₅
Molecular Weight:	99.17
Appearance:	Transparent Liquid
Odor:	Strong, amine-like odor.
Melting Point:	-50 °C
Boiling Point:	106-107 °C (lit.)
Density:	0.816 g/mL at 25 °C (lit.)
Solubility:	Miscible with water and most organic solvents (e.g., ethanol, ether, benzene).
Flash Point:	38 °F
Nature:	Highly flammable liquid and vapor, corrosive, toxic by ingestion and inhalation.
RIDADR:	UN 2399 3/PG 2
Chemical Structure:

Our commitment to delivering high-purity N-Methylpiperidine ensures a reliable and efficient component for your complex manufacturing and synthesis processes.

Primary Applications of N-Methylpiperidine (1-Methylpiperidine)

N-Methylpiperidine's strong basicity, tertiary amine nature, and favorable solvent properties make it an incredibly valuable and versatile chemical with applications spanning numerous industries:

1. Pharmaceutical Synthesis:

   N-Methylpiperidine is a crucial intermediate and building block in the production of various active pharmaceutical ingredients (APIs). Its derivatives are used in the synthesis of drugs targeting diverse therapeutic areas, where a specific tertiary amine or piperidine moiety is required for biological activity.

2. Agrochemical Manufacturing:

   It serves as a key building block in the synthesis of a wide range of agrochemicals, including certain herbicides, insecticides, and fungicides. The incorporation of the N-methylpiperidine structure can enhance the biological activity or stability of these crop protection agents.

3. Chemical Reagent & Catalyst:

   Due to its strong basicity and nucleophilicity, N-Methylpiperidine is widely employed as a highly effective reagent or catalyst in various organic synthesis reactions, including dehydrohalogenations, alkylations, and condensation reactions. It can also act as a ligand in transition metal catalysis.

4. Specialty Chemicals and Fine Chemicals:

   Beyond pharmaceuticals and agrochemicals, N-Methylpiperidine is used in the synthesis of various other fine chemicals, including polymerization catalysts, cross-linking agents, and precursors for advanced materials. It's a key starting material for a wide array of substituted piperidine derivatives.

5. Solvent for Reactions:

   Its excellent solvent properties make it suitable for a variety of chemical reactions, particularly those requiring a basic, aprotic environment.

• Exceptional Purity & Consistency: Our N-Methylpiperidine is manufactured to stringent purity specifications, critical for maximizing yields in complex syntheses and ensuring consistent quality in your downstream products.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients handling this versatile material.

Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Acute Toxicity (GHS06), Skin Corrosion (GHS05), Environmental Hazard (GHS09)

• Hazard Statements: Highly flammable liquid and vapor (H225); Toxic if inhaled (H331); Harmful if swallowed (H302); Harmful in contact with skin (H312); Causes severe skin burns and eye damage (H314); Harmful to aquatic life with long lasting effects (H412).

• UN Number: UN 2399

• Hazard Class: 3 (Flammable Liquids)

• Packing Group: II