4-Picoline

Basic Information of 4-Picoline

CAS No.:	108-89-4
EC No.:	203-626-4
Linear Formula:	CH₃–C₅H₄N
Molecular Weight:	93.13
Appearance:	Transparent Liquid
Odor:	Distinctive, unpleasant odor.
Melting point:	2.4 °C (lit.)
Boiling point:	145 °C (lit.)
Density:	0.957 g/mL at 25 °C (lit.)
Solubility:	Miscible with water, ethanol, ether, and most organic solvents.
Flash point:	134 °F
Nature:	Flammable liquid and vapor, harmful.
RIDADR:	UN 2313 3/PG 3
Chemical Structure:

Our commitment to delivering high-purity 4-Picoline ensures a reliable and efficient component for your complex manufacturing and synthesis processes.

Primary Applications of 4-Picoline (γ-Picoline)

4-Picoline's unique structure and reactivity, particularly the activated methyl group, make it an incredibly valuable and versatile chemical intermediate with applications spanning numerous industries:

1. Pharmaceutical Synthesis (Isoniazid & Vitamin B6 Precursors):

   4-Picoline is a critical precursor in the synthesis of Isoniazid, a frontline drug used for the treatment and prevention of tuberculosis. Its oxidation leads to Isonicotinic acid, a key intermediate for Isoniazid. Furthermore, 4-Picoline derivatives are important for synthesizing Vitamin B6 (Pyridoxine) and its related forms.

2. Agrochemical Manufacturing:

   It serves as a key building block in the synthesis of a variety of agrochemicals, including certain herbicides and fungicides. The pyridine ring structure contributes to the biological activity of these crop protection agents.

3. Specialty Chemicals and Fine Chemicals:

   Due to its reactive methyl group, 4-Picoline can undergo various transformations (e.g., oxidation, halogenation, condensation) to yield a diverse array of fine chemicals, including 4-pyridinecarboxylic acid and its derivatives, used in various organic syntheses.

4. Polymer Additives:

   Some derivatives of 4-Picoline can be used as additives in polymer formulations to impart specific properties.

5. Solvent and Reagent:

   While primarily an intermediate, 4-Picoline can also serve as a specialty solvent or as a reagent in specific organic reactions due to its basicity and ability to participate in various chemical transformations.

• Exceptional Purity & Consistency: Our 4-Picoline is manufactured to stringent purity specifications, critical for maximizing yields in complex syntheses like Isoniazid production and ensuring consistent quality in all your downstream products.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients handling this versatile material.

Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Acute Toxicity, Oral (GHS06), Acute Toxicity, Dermal (GHS06), Acute Toxicity, Inhalation (GHS06), Skin Irritation (GHS07), Eye Irritation (GHS07)

• Hazard Statements: Flammable liquid and vapor; harmful if swallowed, in contact with skin, or inhaled; causes skin irritation; causes serious eye irritation.

• UN Number: UN 2313

• Hazard Class: 3 (Flammable Liquids)

• Packing Group: III