Diethyl Phosphite

Basic Information of Diethyl Phosphite

CAS No.:	762-04-9
EC No.:	212-091-6
Linear Formula:	(C₂H₅O)₂P(O)H
Molecular Weight:	138.1
Appearance:	Transparent Liquid
Melting point:	-70 °C
Boiling point:	50-51 °C/2 mmHg (lit.)
Density:	1.072 g/mL at 25 °C (lit.)
Solubility:	Soluble in many organic solvents such as alcohols, ethers, and benzene. Reacts slowly with water to hydrolyze.
Flash point	180 °F
Nature:	Exhibits tautomerism between phosphite and phosphonate forms. Acts as a reducing agent and a nucleophile.
RIDADR:	UN 3278 3/PG 3
Chemical Structure:

Our commitment to delivering high-purity Diethyl Phosphite ensures a reliable and efficient component for your critical chemical syntheses, offering consistent quality for diverse industrial needs.

Primary Applications of Diethyl Phosphite

Diethyl Phosphite's unique reactivity and versatility make it an indispensable compound with applications across numerous industries:

1. Chemical Intermediate:

   It is a fundamental building block in the synthesis of a wide array of organic compounds, particularly in the production of phosphonates. These derivatives are crucial for various applications, including water treatment chemicals, chelating agents, and flame retardants.

2. Horner-Wadsworth-Emmons (HWE) Reaction:

   It is a key starting material for generating phosphonate carbanions used in the Horner-Wadsworth-Emmons reaction. This reaction is highly valuable in organic synthesis for the stereoselective formation of carbon-carbon double bonds (olefins) from aldehydes and ketones.

3. Arbuzov Reaction:

   Diethyl Phosphite can undergo the Arbuzov reaction with alkyl halides to form phosphonates, which are versatile intermediates in different chemical syntheses.

4. Reducing Agent:

   Due to the presence of a P-H bond, it acts as a mild reducing agent in various chemical transformations, offering controlled reduction in specific synthetic routes.

5. Pesticide and Agrochemical Synthesis:

   It is used in the manufacturing of various pesticides and agrochemicals, particularly those with organophosphorus structures, contributing to crop protection and agricultural efficiency.

6. Pharmaceutical Intermediates:

   Diethyl Phosphite is utilized in the synthesis of certain pharmaceutical intermediates and active pharmaceutical ingredients (APIs), enabling the creation of complex drug molecules.

7. Polymer Additives:

   It finds application as an antioxidant and stabilizer in certain polymer formulations, improving their performance and extending their lifespan.

• Exceptional Purity & Reactivity: Our Diethyl Phosphite is manufactured to stringent purity specifications, crucial for ensuring high yields and clean reactions in complex organic syntheses and industrial processes.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients.

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