Methyltriphenylphosphonium Bromide

Basic Information of Methyltriphenylphosphonium Bromide

CAS No.:	1779-49-3
EC No.:	217-218-9
Linear Formula:	CH₃P(C₆H₅)₃Br
Molecular Weight:	357.22
Appearance:	White to off-white crystalline powder.
Melting point:	230-234 °C (lit.)
Solubility:	Soluble in various organic solvents, including dichloromethane, tetrahydrofuran (THF), and alcohols. Sparingly soluble in water.
Nature:	A phosphonium salt that forms a reactive ylide (methylene triphenylphosphorane) when treated with a strong base. The ylide is sensitive to moisture and air.
RIDADR:	UN 3464 6.1/PG 3
Chemical Structure:

Our commitment to delivering high-purity Methyltriphenylphosphonium Bromide ensures a reliable and efficient component for your critical chemical syntheses, offering consistent quality for diverse research and industrial needs.

Primary Applications of Methyltriphenylphosphonium Bromide

This specialized Wittig reagent's unique reactivity profile makes it an indispensable tool in advanced organic synthesis, particularly for the precise formation of terminal methylene groups:

1. Wittig Reaction for Methylene Olefin Synthesis:

   Its primary application is as a key reagent in the Wittig reaction. When deprotonated by a strong base, it forms a methylene triphenylphosphorane ylide. This ylide then reacts with aldehydes or ketones to form new carbon-carbon double bonds, specifically synthesizing methylene ($=CH_2$) derivatives from the carbonyl group.

2. Pharmaceutical and Agrochemical Synthesis:

   The ability to precisely introduce terminal methylene groups is invaluable in the synthesis of complex organic molecules. This includes intermediates for pharmaceuticals, agrochemicals, and other fine chemicals where controlled carbon chain elongation and specific double bond formation are essential.

3. Steroid and Terpene Synthesis:

   It is frequently employed in the synthesis of natural products, including steroids, terpenes, and other complex natural compounds, where the formation of specific olefinic structures is critical for biological activity.

4. Specialty Chemicals Production:

   It plays a role in the production of various specialty chemicals, including some flavors, fragrances, and materials science applications, where precise structural modifications are required.

• Exceptional Purity & Reactivity: Our Methyltriphenylphosphonium Bromide is manufactured to stringent purity specifications, crucial for ensuring high yields and selectivity in sensitive Wittig reactions and other complex organic syntheses.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients.

Hazards Classification

• GHS Classification: Acute Toxicity (GHS06), Skin Irritation (GHS07), Eye Irritation (GHS07)

• Hazard Statements: Harmful if swallowed; causes skin irritation; causes serious eye irritation.

• UN Number: UN 3464

• Hazard Class: 6.1 (Toxic Substances)

• Packing Group: III