Dichloroacetyl Chloride

Dichloroacetyl chloride is a corrosive, fuming liquid that acts as a powerful acylating agent in organic chemistry. It readily reacts with alcohols, amines, and other nucleophiles to form esters, amides, and related derivatives while also serving as a precursor to dichloroacetic acid through hydrolysis. Its high reactivity requires handling under controlled conditions to prevent unwanted side reactions and ensure process safety.

Basic Information

CAS No.	79-36-7
EC No.	201-199-9
Linear Formula	Cl2CHCOCl
Molecular Weight	147.38 g/mol
Appearance	Colorless to yellow fuming liquid with pungent odor
Melting Point	Not available (lit.)
Boiling point	107-108 °C (lit.)
Density	1.53 g/mL at 20 °C (lit.)
RIDADR	UN 1765 Class 8 PG II
Chemical Structure

Key Applications

• Major industrial intermediate: Dichloroacetyl chloride is primarily used as a key intermediate in the manufacture of dichloroacetic acid and its derivatives for pharmaceutical and agrochemical applications.

• Acylating agent in synthesis: It serves as an effective reagent for introducing the dichloroacetyl group in organic synthesis for fine chemicals and specialty compounds.

• Pharmaceutical applications: Employed in the production of active pharmaceutical ingredients and intermediates, particularly in certain drug syntheses.

• Agrochemical production: Used in the synthesis of pesticides and herbicides as a building block for active ingredients.

• Laboratory and research use: Applied as a reagent in analytical chemistry and research for acylation reactions and derivative preparation.

• High purity specifications and strict batch consistency: Our dichloroacetyl chloride meets demanding quality requirements with rigorous testing to support reliable performance in sensitive acylation and intermediate synthesis processes.

• Complete SDS, COA and dangerous goods documentation available: Full compliance packages including safety data sheets and certificates of analysis facilitate regulatory adherence for corrosive chemical procurement and transport.

• Professional technical communication and responsive service: Our experienced team provides dedicated assistance with product handling guidance, packaging options, and technical inquiries to support safe and efficient sourcing.

Hazards Classification

GHS Classification: Skin corrosion (Category 1A) GHS05; Serious eye damage (Category 1) GHS05; Acute toxicity, dermal (Category 3) GHS06; Hazardous to the aquatic environment - Acute (Category 1) GHS09.

Hazard Statements: H314 - Causes severe skin burns and eye damage. H318 - Causes serious eye damage. H311 - Toxic in contact with skin. H400 - Very toxic to aquatic life.

UN Number: UN 1765 | Hazard Class: 8 (Corrosive) | Packing Group: II