Allyl Chlorooxalate

Allyl chlorooxalate is a reactive liquid ester-acid chloride that combines allyl and oxalyl functionalities, making it valuable for selective acylation and cross-coupling reactions in complex molecule synthesis. It is particularly important in the construction of beta-lactam frameworks found in modern antibiotics. The compound's dual reactivity demands careful handling under inert or controlled conditions to maintain stability and prevent decomposition.

Basic Information

CAS No.	74503-07-4
EC No.	277-900-7
Linear Formula	CH2=CHCH2OC(O)C(O)Cl
Molecular Weight	148.54 g/mol
Appearance	Liquid
Melting Point	Not available (lit.)
Boiling point	50-51 °C at 12 Torr (lit.)
Density	1.213 g/mL at 25 °C (lit.)
RIDADR	UN 2920 Class 3 (8) PG II
Chemical Structure

Key Applications

• Pharmaceutical intermediate for penem antibiotics: Allyl chlorooxalate is a key building block in the industrial synthesis of Sulopenem and other penem-class antibiotics used for treating resistant bacterial infections.

• Reactive acylating agent in synthesis: It functions as an effective reagent for introducing allyloxalyl or related functional groups during the preparation of complex pharmaceutical intermediates and fine chemicals.

• Specialty chemical and API production: Employed in the manufacture of active pharmaceutical ingredients and advanced intermediates requiring precise oxalyl or ester modifications.

• Organic synthesis applications: Used in research and development laboratories for constructing functionalized molecules in medicinal chemistry and materials science projects.

• Custom synthesis and contract manufacturing: Serves as a versatile starting material for custom synthesis routes in the pharmaceutical and specialty chemical industries.

• High purity specifications and strict batch consistency: Our allyl chlorooxalate is manufactured and tested to meet the exacting standards required for pharmaceutical intermediate applications and sensitive synthetic processes.

• Complete SDS, COA and dangerous goods documentation available: Comprehensive regulatory documentation including safety data sheets and certificates of analysis supports compliance for international transport and procurement of this reactive material.

Hazards Classification

GHS Classification: Flammable liquids (Category 3) GHS02; Skin corrosion (Category 1B) GHS05; Acute toxicity, oral (Category 4) GHS07.

Hazard Statements: H226 - Flammable liquid and vapour. H314 - Causes severe skin burns and eye damage. H302 - Harmful if swallowed.

UN Number: UN 2920 | Hazard Class: 3 (Flammable liquid) subsidiary risk 8 (Corrosive) | Packing Group: II