Chloro PEG3 alcohol

Chloro PEG3 alcohol (CAS 5197-62-6), also known as 2-[2-(2-chloroethoxy)ethoxy]ethanol, is a monodisperse chloro-functional polyethylene glycol derivative. It features a terminal chloro group and a terminal hydroxyl group connected by a triethylene glycol chain, making it a useful intermediate for organic synthesis and linker construction.

Basic Information

CAS No.	5197-62-6
EC No.	225-984-0
Linear Formula	Cl(CH₂CH₂O)₂CH₂CH₂OH
Molecular Weight	168.62 g/mol
Appearance	Colorless to yellow liquid
Melting Point	Not available (typical reference)
Boiling point	256–258 °C (lit.)
Density	1.163 g/mL at 25 °C (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place. Protect from moisture and incompatible materials.
Chemical Structure

Key Applications

• Molecular linker intermediate: The terminal chloro group enables nucleophilic substitution reactions for attaching PEG chains to amines, thiols or other nucleophiles in linker synthesis.

• Organic synthesis intermediate: Used as a building block for preparing PEGylated compounds and ethylene glycol-based derivatives in fine chemical manufacturing.

• Fine chemical intermediate: Serves as a versatile reagent for introducing hydrophilic chloro-PEG segments into complex organic molecules during specialty synthesis.

• Pharmaceutical intermediate: Employed in the synthesis of drug intermediates and PEGylated active pharmaceutical ingredients requiring a defined spacer.

• Laboratory research: Widely utilized in medicinal chemistry and process research laboratories for developing functional PEG linkers and studying substitution chemistry.

• Consistent product quality: High-purity Chloro PEG3 alcohol is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Available in small laboratory quantities in sealed glass bottles or HDPE containers; bulk volumes supplied in suitable HDPE drums. Customized liquid packaging options can be arranged upon request.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated place. Protect from moisture and incompatible materials. Recommended storage at ambient or lower temperature.

• Handling of opened containers: After opening, protect the product from moisture and air exposure. Use contents promptly and reseal the container tightly for remaining material.

Safety and Handling

• General handling: Work in a well-ventilated area or chemical fume hood. Follow standard laboratory practices for handling organic compounds containing chloro and alcohol functional groups.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before handling, storage, or transportation to ensure appropriate precautions are observed.