mPEG3 amine

mPEG3 amine (CAS 74654-07-2), also known as m-PEG3-Amine or MeO-PEG3-NH2, is a monodisperse methoxy-terminated polyethylene glycol derivative featuring a terminal primary amine group. This structure makes it a valuable molecular linker intermediate for bioconjugation and organic synthesis applications.

Basic Information

CAS No.	74654-07-2
EC No.	Not available
Linear Formula	CH₃O(CH₂CH₂O)₂CH₂CH₂NH₂
Molecular Weight	163.21 g/mol
Appearance	Colorless to light yellow liquid
Melting Point	Not available (typical reference)
Boiling point	106 °C at 11 Torr (lit.)
Density	0.978 ± 0.06 g/cm³ (Predicted)
Solubility	Soluble in water and polar organic solvents such as DMSO, DCM, and DMF
Storage Conditions	Keep in a tightly closed container in a cool, dry and well-ventilated place under inert atmosphere. Protect from moisture and air. Recommended storage at 2-8°C.
Chemical Structure

Key Applications

• PEG linker intermediate: Serves as a defined methoxy-terminated PEG3 spacer with a reactive primary amine for constructing PROTAC molecules and cleavable ADC linkers.

• Bioconjugation research: The terminal amine enables efficient coupling to carboxylic acids, NHS esters, and carbonyl groups for biomolecule modification and PEGylation studies.

• Fine chemical intermediate: Acts as a versatile building block for introducing hydrophilic methoxy-PEG segments into complex organic molecules during specialty synthesis.

• Process development: Supports laboratory and pilot-scale efforts in optimizing synthetic routes that incorporate precise PEG-based linkers with controlled spacer lengths.

• Laboratory research: Widely used in medicinal chemistry laboratories for exploring PEGylation strategies and developing functional conjugates with tailored hydrophilic properties.

• Consistent product quality: High-purity mPEG3 amine is sourced through established channels with routine quality coordination to meet fine chemical specifications.

• SDS and COA support: Comprehensive product documentation including SDS and COA is available upon request to facilitate regulatory review and international procurement.

• Packaging and technical service: Responsive technical communication and assistance with appropriate packaging selection based on order quantity and product characteristics.

Packaging and Storage

• Packaging: Available in small laboratory quantities in sealed containers or sample bottles; larger volumes supplied in suitable HDPE drums. Customized liquid packaging options can be arranged based on specific requirements.

• Storage: Store in a tightly closed container in a cool, dry, well-ventilated place under inert atmosphere. Protect from moisture and air. Long-term storage recommended at 2-8°C.

• Handling of opened containers: After opening, minimize exposure to air and moisture. Use the contents promptly and reseal the container tightly to maintain product integrity.

Safety and Handling

• General handling: Work in a well-ventilated area or chemical fume hood. Follow standard laboratory practices for handling organic compounds containing amine functional groups.

• Personal protection: Wear suitable protective gloves, safety goggles, and protective clothing to prevent skin and eye contact during handling.

• Documentation review: Consult the current Safety Data Sheet (SDS) before handling, storage, or transportation to ensure appropriate precautions are observed.