1-(3-Chloropropoxy)-4-methoxybenzene

1-(3-Chloropropoxy)-4-methoxybenzene (CAS 1716-42-3) is a bifunctional aromatic ether featuring a reactive chloropropyl chain attached to a methoxy-substituted benzene ring. This structure makes it a valuable alkylating agent in organic synthesis for the construction of longer-chain aryloxy derivatives.

Basic Information

CAS No.	1716-42-3
EC No.	Not available
Linear Formula	C10H13ClO2
Molecular Weight	200.66
Appearance	Colorless to light yellow clear liquid
Solubility	Soluble in common organic solvents
Storage Conditions	Store in a tightly closed container in a cool, dry place. Protect from moisture and light.
Chemical Structure

Key Applications

• Reactive alkylation intermediate: 1-(3-Chloropropoxy)-4-methoxybenzene serves as an effective alkylating agent for introducing the 3-(4-methoxyphenoxy)propyl group into target molecules. It is relevant to Alkoxy Propanols and Propylene Glycol Ethers for Pharmaceutical Synthesis, where alkoxy-functional intermediates enable controlled chain extension and functionalization.

• Chloroalkyl functionalization: The terminal chloride group provides a reactive site for nucleophilic substitution, allowing further derivatization into amines, ethers, or other functional groups. This reactivity is part of the broader  alkoxy ether application category.

• Fine chemical intermediate: Used in the synthesis of specialty chemicals and pharmaceutical intermediates, particularly where stepwise functional group transformation is required.

• Aromatic compound synthesis: Facilitates the preparation of substituted aromatic systems through nucleophilic substitution and side-chain modification, supporting the development of advanced functional molecules.

• Laboratory research: Applied in research for synthetic route development, linker design, and exploration of bioactive molecule candidates involving aryl ether structures.

• Process development: Supports route optimization and scale-up in processes requiring reliable chloroalkyl aryl ether intermediates with consistent reactivity.

1-(3-Chloropropoxy)-4-methoxybenzene belongs to the Alkoxy Propanols & Glycol Ethers application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering alkoxy-functional intermediates, reactive linkers, and ether-based building blocks for API and fine chemical synthesis.

• Flexible global supply: Established international logistics networks ensure stable supply from laboratory to bulk scale for fine chemical customers worldwide.

• SDS and COA support: Full SDS, COA, and supporting technical documentation provided upon request to facilitate quality review and regulatory compliance.

• Packaging and technical service: Flexible packaging options including 25L/200L HDPE drum, supported by responsive technical communication for synthesis needs.