2,2,3,3-Tetrafluoropropyl glycidyl ether

2,2,3,3-Tetrafluoropropyl glycidyl ether (CAS 19932-26-4) is a fluorinated epoxide that functions as a reactive intermediate for the incorporation of tetrafluoropropyl ether moieties in organic molecules. The glycidyl group enables ring-opening reactions while the fluorinated chain imparts unique properties to the resulting compounds.

Basic Information

CAS No.	19932-26-4
EC No.	243-431-1
Linear Formula	C6H8F4O2
Molecular Weight	188.12
Appearance	Colorless to light yellow clear liquid
Melting Point	Not available (typical reference)
Boiling point	50 °C at 4 mmHg (lit.)
Density	1.327 g/mL at 25 °C (lit.)
Solubility	Soluble in common organic solvents
Storage Conditions	Store in a cool, dry place away from heat and ignition sources. Keep container tightly closed.
Chemical Structure

Key Applications

• Epoxide building block for synthesis: 2,2,3,3-Tetrafluoropropyl glycidyl ether is a highly reactive epoxide intermediate used in ring-opening reactions to introduce fluorinated ether linkages into target molecules. It is a representative product in Glycidyl Ethers and Epoxy Propyl Ethers for API Synthesis, where epoxide functionality enables versatile downstream transformations.

• Fluorinated functional materials: The tetrafluoropropyl group imparts enhanced chemical resistance, thermal stability, and hydrophobicity, making this compound valuable in advanced materials and high-performance systems. These applications are also covered in  Fluorinated Ethers & Trifluoropropoxy Derivatives for High-Value API.

• Fine chemical and pharmaceutical intermediate: Widely used in the preparation of fluorinated specialty chemicals, pharmaceutical intermediates, and bioactive molecules, where fluorine incorporation improves metabolic stability and molecular performance.

• Functional group introduction: Enables selective incorporation of tetrafluoropropyl ether groups through controlled epoxide chemistry, supporting the design of molecules with tailored physicochemical properties.

• Laboratory research: Applied in research for developing fluorinated synthetic methodologies and novel functional materials, especially in medicinal chemistry and advanced polymer systems.

• Process development: Supports route optimization and scale-up in processes requiring stable fluorinated epoxide intermediates with consistent reactivity and performance.

2,2,3,3-Tetrafluoropropyl glycidyl ether belongs to both the    Glycidyl Ethers & Epoxy Building Blocks and Fluorinated Ethers application categories, and is part of our broader portfolio of    Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering high-value epoxide intermediates, fluorinated building blocks, and advanced materials for API and specialty chemical synthesis.

• Flexible global supply: Stable international logistics ensure dependable delivery from laboratory scale to bulk quantities for fine chemical customers worldwide.

• SDS and COA support: Complete SDS, COA, and technical documentation available upon request to support quality review and international procurement.

• Packaging and technical service: Flexible packaging in 1 kg, 5 kg, and 25 kg fiber drums with PE liners, accompanied by responsive technical communication for application needs.