3-Picoline

Basic Information of 3-Picoline

CAS No.:	108-99-6
EC No.:	203-636-9
Linear Formula:	CH₃–C₅H₄N
Molecular Weight:	93.13
Appearance:	Transparent Liquid
Odor:	203-636-9
Melting point:	-19 °C (lit.)
Boiling point:	144 °C (lit.)
Density:	0.957 g/mL at 25 °C (lit.)
Solubility:	Miscible with water, ethanol, ether, and most organic solvents.
Flash point:	97 °F
Nature:	Flammable liquid and vapor, harmful.
RIDADR:	UN 2313 3/PG 3
Chemical Structure:

Our commitment to delivering high-purity 3-Picoline ensures a reliable and efficient component for your complex manufacturing and synthesis processes.

Primary Applications of 3-Picoline (β-Picoline)

3-Picoline's unique structure and reactivity make it an incredibly valuable and versatile chemical intermediate with applications spanning numerous industries:

1. Niacin (Vitamin B3) Production:

   The most significant application of 3-Picoline is its oxidation to produce Nicotinic acid, which is then converted into Niacin and Niacinamide (Vitamin B3). Niacin is a vital nutrient used in food fortification, pharmaceuticals, and animal feed.

2. Agrochemical Manufacturing:

   It serves as a key building block in the synthesis of a wide range of agrochemicals, including certain herbicides, insecticides, and fungicides. Its pyridine ring structure contributes to the biological activity of these crop protection agents.

3. Pharmaceutical Synthesis:

   3-Picoline is a critical intermediate in the production of various active pharmaceutical ingredients (APIs), particularly those requiring a 3-substituted pyridine moiety. Its derivatives are used in anti-tubercular drugs and other therapeutic compounds.

4. Specialty Chemicals and Fine Chemicals:

   Beyond Niacin, 3-Picoline can be transformed into other valuable pyridine derivatives, including various pyridine carboxylic acids and their esters, which find applications in diverse fine chemical syntheses.

5. Solvent and Reagent:

   While primarily an intermediate, 3-Picoline can also be used as a specialty solvent or as a reagent in specific organic reactions due to its basicity and unique solubility properties.

• Exceptional Purity & Consistency: Our 3-Picoline is manufactured to stringent purity specifications, critical for maximizing conversion to Niacin and ensuring optimal performance in all your downstream synthesis processes.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients handling this versatile material.

Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Acute Toxicity, Oral (GHS06), Acute Toxicity, Dermal (GHS06), Acute Toxicity, Inhalation (GHS06), Skin Irritation (GHS07), Eye Irritation (GHS07)

• Hazard Statements: Flammable liquid and vapor; harmful if swallowed, in contact with skin, or inhaled; causes skin irritation; causes serious eye irritation.

• UN Number: UN 2313

• Hazard Class: 3 (Flammable Liquids)

• Packing Group: III