15-Crown-5

15-Crown-5 (CAS 33100-27-5) is a macrocyclic polyether widely used in organic synthesis as a selective complexing agent for sodium cations. It functions effectively in phase-transfer catalysis, enabling efficient reactions between aqueous and organic phases while improving ion solubility in non-polar media.

Basic Information

CAS No.	33100-27-5
EC No.	251-379-6
Linear Formula	C10H20O5
Molecular Weight	220.26
Appearance	Colorless to light yellow clear liquid
Melting Point	-20 °C (lit.)
Boiling point	93-96 °C at 0.05 mmHg (lit.)
Density	1.11 g/mL at 20 °C (lit.)
Solubility	Soluble in water and most organic solvents
Storage Conditions	Store under inert gas in a cool, dry place. Hygroscopic; protect from moisture.
Chemical Structure

Key Applications

• Phase-transfer catalysis: 15-Crown-5 is widely used as a phase-transfer catalyst in organic synthesis, selectively complexing sodium ions to enhance anion reactivity in biphasic systems. It is a representative product in Crown Ethers (15-Crown-5 & 18-Crown-6) for Phase Transfer & API Synthesis, where selective cation binding significantly improves reaction efficiency and yield.

• Selective ion complexation: Due to its cavity size and binding affinity, 15-Crown-5 exhibits high selectivity for sodium ions, enabling controlled ion transport and coordination in both synthetic and analytical applications. This functionality is a key focus of the  crown ether application category.

• Fine chemical synthesis: Employed in fine chemical production where cation complexation enhances reaction selectivity, conversion, and overall process performance in specialty syntheses.

• Supramolecular and coordination chemistry: Widely applied in research for host–guest chemistry, ion recognition, and supramolecular system design, supporting advanced functional molecule development.

• Process development: Supports route optimization and process scale-up in organic synthesis, particularly in reactions requiring efficient ion transport, controlled reactivity, and improved selectivity.

15-Crown-5 belongs to the Crown Ethers for Phase Transfer Catalysis application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering crown ethers, ion-complexing agents, and advanced catalytic systems for API and specialty chemical synthesis.

• Flexible global supply: Stable international logistics support laboratory, pilot, and bulk procurement with reliable delivery to fine chemical customers worldwide.

• SDS and COA support: Full SDS, COA, and regulatory documentation available upon request to facilitate quality review and international procurement.

• Packaging and technical service: Flexible packaging in 25L/200L HDPE drum, supported by responsive technical communication for application needs.