18-Crown-6

18-Crown-6 (CAS 17455-13-9) is a macrocyclic polyether recognized for its selective binding of potassium cations. It serves as an efficient phase-transfer catalyst that enhances the reactivity of potassium salts in non-polar organic solvents during synthetic transformations.

Basic Information

CAS No.	17455-13-9
EC No.	241-473-5
Linear Formula	C12H24O6
Molecular Weight	264.32
Appearance	White or colorless crystalline solid
Melting Point	37-40 °C (lit.)
Boiling point	116 °C at 0.2 mmHg (lit.)
Density	1.175 g/cm³ (lit.)
Solubility	Soluble in water and common organic solvents (chloroform, acetonitrile, dichloromethane)
Storage Conditions	Store in a tightly closed container in a cool, dry place. Hygroscopic; protect from moisture and light.
Chemical Structure

Key Applications

• Phase-transfer catalysis: 18-Crown-6 is widely used as a highly efficient phase-transfer catalyst, selectively complexing potassium ions (K⁺) to enhance anion reactivity in biphasic systems. It is a core product in  Crown Ethers (15-Crown-5 & 18-Crown-6) for Phase Transfer & API Synthesis, where strong cation binding significantly improves reaction rates and yields.

• Selective ion complexation: With an optimal cavity size for potassium ions, 18-Crown-6 exhibits excellent selectivity and binding strength, enabling precise ion transport and coordination in both synthetic and analytical systems. This function is central to the crown ether application category.

• Fine chemical synthesis: Used in fine chemical production to enhance selectivity and efficiency in potassium-mediated reactions, especially in the synthesis of high-value intermediates and specialty compounds.

• Supramolecular and coordination chemistry: Widely applied in research involving host–guest chemistry, supramolecular assemblies, and ion recognition systems, supporting advanced functional material and molecule design.

• Process development: Supports route optimization and scale-up by enabling milder reaction conditions, improved selectivity, and efficient ion transport in complex organic processes.

18-Crown-6 belongs to the Crown Ethers for Phase Transfer Catalysis application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering crown ethers, ion-complexing agents, and advanced catalytic systems for API and specialty chemical synthesis.

• Flexible global supply: Established logistics networks ensure stable supply from laboratory to bulk scale for international fine chemical customers.

• SDS and COA support: Complete SDS, COA, and technical documentation provided upon request to streamline sourcing and regulatory compliance.

• Packaging and technical service: Flexible options in 1 kg, 5 kg, and 25 kg fiber drums with PE liners, backed by responsive technical assistance for application support.