3-Hydroxyoxetane

Basic Information

CAS No.	7748-36-9
EC No.	663-648-9
Linear Formula	C3H6O2
Molecular Weight	74.08
Appearance	Colorless to light yellow clear liquid
Melting Point	14 °C (lit.)
Boiling point	153 °C (lit.)
Density	1.167 g/mL at 25 °C (lit.)
Solubility	Soluble in chloroform and methanol
Storage Conditions	Store in a tightly closed container under inert atmosphere at 2-8 °C in a cool, dry place
Chemical Structure

Key Applications

• Organic synthesis intermediate: 3-Hydroxyoxetane serves as a key building block for introducing oxetane rings into organic molecules, enabling access to strained cyclic ether structures. It is an important compound within Cyclic Ethers (Tetrahydropyran & Oxetane) for API Building Blocks, where ring strain and compact polarity are leveraged in synthesis design.

• Medicinal chemistry applications: Oxetane-containing structures are widely used in drug design as bioisosteres to improve metabolic stability, solubility, and lipophilicity. This application is a core topic within the cyclic ether application category, particularly in modern pharmaceutical R&D.

• Fine chemical intermediate: Used in the production of specialty chemicals and pharmaceutical intermediates featuring oxetane motifs, especially where enhanced physicochemical properties are required.

• Functional molecule construction: Facilitates incorporation of strained cyclic ether units into complex molecules, supporting the development of advanced intermediates with improved molecular performance.

• Laboratory research: Ideal for exploratory synthesis, medicinal chemistry programs, and method development involving small-ring heterocycles and functional group transformations.

• Process development: Supports route optimization, pilot-scale synthesis, and scalable manufacturing of custom intermediates for pharmaceutical and specialty chemical applications.

3-Hydroxyoxetane belongs to the Cyclic Ethers (Tetrahydropyran & Oxetane) application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering cyclic ether building blocks, oxetane chemistry, and advanced intermediates for API and drug discovery.

• SDS and COA support: Full SDS, COA, and technical documentation are provided upon request to facilitate quality assurance, regulatory compliance, and export processes.

• Packaging and technical service: Flexible packaging options such as 1 kg, 5 kg, and 25 kg HDPE drums with PE liner, combined with responsive technical assistance tailored to your project specifications.