Trimethyl Phosphite

Basic Information of Trimethyl Phosphite

CAS No.:	121-45-9
EC No.:	204-471-5
Linear Formula:	P(OCH₃)₃
Molecular Weight:	124.08
Appearance:	Transparent Liquid
Melting point:	−78 °C(lit.)
Boiling point:	111-112 °C(lit.)
Density:	1.052 g/mL at 25 °C(lit.)
Solubility:	Miscible with many organic solvents such as alcohols, ethers, and aromatic hydrocarbons. Reacts with water (hydrolyzes).
Flash point	82 °F
Nature:	Reactive organophosphorus compound. Can act as a reducing agent and a nucleophile. Susceptible to hydrolysis in the presence of water.
RIDADR:	UN 2329 3/PG 2
Chemical Structure:

Our commitment to delivering high-purity Trimethyl Phosphite ensures a reliable and efficient component for your critical chemical syntheses, offering consistent quality for diverse industrial needs.

Primary Applications of Trimethyl Phosphite

Trimethyl Phosphite's unique reactivity and versatility make it an indispensable compound with applications across numerous industries:

1. Chemical Intermediate:

   It is a fundamental building block in the synthesis of a wide array of organophosphorus compounds, including phosphonates, phosphonites, and other derivatives. These intermediates are crucial for various industrial applications.

2. Ligand in Coordination Chemistry:

   Trimethyl Phosphite is widely used as a ligand in the synthesis of transition metal complexes. Its ability to coordinate with metals is essential in homogeneous catalysis, forming active catalyst species for various organic transformations.

3. Reducing Agent:

   Due to its oxidation state, it acts as an effective reducing agent in many organic reactions, often used for deoxygenation, desulfurization, and other reduction processes.

4. Arbuzov and Perkow Reactions:

   It is a key reactant in the Arbuzov reaction (for synthesizing phosphonates) and the Perkow reaction (for synthesizing enol phosphates), which are important methods for creating phosphorus-carbon bonds and functionalized olefins.

5. Pesticide and Agrochemical Synthesis:

   It is used in the manufacturing of various pesticides and agrochemicals, particularly those with organophosphorus structures, contributing to crop protection and agricultural efficiency.

6. Pharmaceutical Intermediates:

   Trimethyl Phosphite is utilized in the synthesis of certain pharmaceutical intermediates and active pharmaceutical ingredients (APIs), enabling the creation of complex drug molecules.

7. Polymer Additives:

   It finds application as an antioxidant and stabilizer in certain polymer formulations, improving their performance and extending their lifespan.

• Exceptional Purity & Reactivity: Our Trimethyl Phosphite is manufactured to stringent purity specifications, crucial for ensuring high yields and clean reactions in complex organic syntheses and industrial processes.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients.

Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Acute Toxicity (GHS06), Skin Corrosion/Irritation (GHS07)

• Hazard Statements: Highly flammable liquid and vapor; toxic if swallowed or in contact with skin; causes skin irritation.

• UN Number: UN 2329

• Hazard Class: 3 (Flammable Liquids)

• Packing Group: II