Trifluoroacetic Acid

Basic Information of Trifluoroacetic Acid

Trifluoroacetic Acid (CAS No. 76-05-1) is manufactured to the highest purity standards, ensuring optimal performance and reliability for your most demanding applications:

CAS No.:	76-05-1
EC No.:	200-929-3
Linear Formula:	CF₃COOH
Molecular Weight:	114.02
Appearance:	Transparent Liquid
Odor:	Pungent, sharp, vinegar-like odor
Melting Point:	-15.2 °C
Boiling point:	72 °C
Density:	1.489 g/mL at 25 °C
Solubility:	Miscible with water and most organic solvents.
Nature:	Extremely corrosive, highly volatile, strong acid (stronger than sulfuric acid), non-oxidizing.
RIDADR:	UN 2699 8/PG 1
Chemical Structure:

Our commitment to delivering high-purity TFA ensures consistent and superior results for your specialized synthesis and analytical needs.

Primary Applications of Trifluoroacetic Acid (TFA)

Trifluoroacetic Acid's unique chemical profile, characterized by its strong acidity and the electron-withdrawing effects of its fluorine atoms, drives its extensive utility:

1. Peptide Synthesis & Protein Chemistry:

   TFA is absolutely critical in solid-phase peptide synthesis (SPPS), where it's used to deprotect N-terminal Boc (tert-butyloxycarbonyl) groups. Its high volatility allows for easy removal after reaction, making it ideal for the sequential synthesis of peptides and proteins.

2. Pharmaceutical & Agrochemical Manufacturing:

   As a powerful catalyst and solvent, TFA plays a vital role in the synthesis of various active pharmaceutical ingredients (APIs) and agrochemicals. It's used in numerous reactions requiring strong acidic conditions, such as esterifications, alkylations, and acylations.

3. Chromatography & Analytical Chemistry:

   TFA is a common mobile phase modifier in High-Performance Liquid Chromatography (HPLC), particularly for separating peptides, proteins, and other polar compounds. Its volatility ensures it won't interfere with subsequent mass spectrometry analysis, making it an ideal ion-pairing reagent.

4. Polymer Science & Advanced Materials:

   Used as a solvent for dissolving various polymers (e.g., polyamides, polyesters) that are otherwise insoluble in common organic solvents. It also serves as a reagent in the synthesis of specialized fluoropolymers and other advanced materials.

5. General Organic Synthesis:

   Beyond its specific applications, TFA acts as a versatile strong acid catalyst, solvent, and reagent for numerous organic reactions, including Friedel-Crafts acylations, deprotections, and oxidation reactions.

• Exceptional Purity: Our TFA is manufactured to the highest purity specifications, crucial for sensitive applications like peptide synthesis and analytical chromatography.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations.

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Hazards Classification

• GHS Classification: Corrosive (GHS05), Acute Toxicity (GHS06), Environmental Hazard (GHS09)

• Hazard Statements: Causes severe skin burns and eye damage; harmful if inhaled; very toxic to aquatic life with long lasting effects.

• UN Number: UN 2699

• Hazard Class: 8 (Corrosive Substances)

• Packing Group: I