Tetrahydropyran

Basic Information

CAS No.	142-68-7
EC No.	205-552-8
Linear Formula	C5H10O
Molecular Weight	86.13
Appearance	Colorless clear liquid
Melting Point	-49 °C (lit.)
Boiling point	88 °C (lit.)
Density	0.881 g/mL at 25 °C (lit.)
Solubility	Slightly soluble in water; miscible with most organic solvents
Storage Conditions	Keep in a tightly closed container in a cool, dry, well-ventilated place away from heat and ignition sources
Chemical Structure

Key Applications

• Organic synthesis intermediate: Tetrahydropyran (THP) is widely used as a solvent and reactive intermediate in organic synthesis, including Grignard reactions and heterocyclic construction. It is a core compound in Cyclic Ethers (Tetrahydropyran & Oxetane) for API Building Blocks, where cyclic ether structures play essential roles in synthesis design.

• Protecting group chemistry: THP is extensively used for the protection of alcohol functional groups via formation of tetrahydropyranyl (THP) ethers, a widely applied strategy in multi-step organic synthesis and API development. This application is a key topic within the cyclic ether application category.

• Fine chemical intermediate: It is employed in the production of specialty chemicals and molecules incorporating tetrahydropyran structural motifs, particularly in pharmaceutical intermediates and advanced organic materials.

• Laboratory research: Ideal for laboratory-scale synthesis, methodology development, and studies involving protecting group strategies and cyclic ether chemistry.

• Process development: Supports scalable route optimization and pilot-scale synthesis, especially in processes requiring selective protection and deprotection steps in complex molecule assembly.

Tetrahydropyran (THP) belongs to the Cyclic Ethers (Tetrahydropyran & Oxetane) application category and is part of our broader portfolio of  Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering cyclic ether building blocks, protecting group chemistry, and API synthesis intermediates.

• SDS and COA support: Complete SDS, COA, and technical documentation are provided upon request to streamline quality review, regulatory compliance, and export procedures.

• Packaging and technical service: Flexible packaging options including 1 kg, 5 kg, and 25 kg HDPE drums with PE liner are available, backed by responsive technical communication for your specific project needs.