Acetonitrile

Basic Information of Acetonitrile

CAS No.:	75-05-8
EC No.:	200-835-2
Linear Formula:	CH₃CN
Molecular Weight:	41.05
Appearance:	Transparent Liquid
Odor:	Sweet, ether-like odor.
Melting point:	45 °C (lit.)
Boiling point:	81-82 °C (lit.)
Density:	0.786 g/mL at 25 °C (lit.)
Solubility:	Miscible with water and many organic solvents (e.g., acetone, benzene, carbon tetrachloride, ethanol, ethyl ether).
Flash point:	48 °F
Nature:	Flammable liquid and vapor, toxic.
RIDADR:	UN 1648 3/PG 2
Chemical Structure:

Our commitment to delivering high-purity Acetonitrile ensures a reliable and efficient component for your critical analytical and synthesis processes.

Primary Applications of Acetonitrile

Acetonitrile's unique properties make it an indispensable solvent and reagent across a wide range of applications:

1. High-Performance Liquid Chromatography (HPLC):

   ACN is one of the most commonly used organic modifiers in HPLC mobile phases due to its low UV absorbance, low viscosity, and ability to elute a wide range of compounds. It provides excellent resolution and sensitivity in analytical separations.

2. Pharmaceutical Manufacturing:

   Acetonitrile is extensively used as a solvent in the synthesis, purification, and formulation of various pharmaceutical active ingredients (APIs) and intermediates. Its ability to dissolve both polar and nonpolar compounds makes it highly versatile.

3. DNA and Peptide Synthesis:

   ACN serves as a crucial solvent in oligonucleotide and peptide synthesis, facilitating coupling reactions and purification steps.

4. Extraction Solvent:

   It is employed as an extraction solvent for fats, oils, and other organic compounds from various matrices in the food, environmental, and pharmaceutical industries.

5. Chemical Synthesis:

   Acetonitrile is a versatile reaction medium for a wide variety of organic reactions, including nucleophilic substitutions, Diels-Alder reactions, and transition metal-catalyzed reactions. It can also act as a nitrile source in some transformations.

6. Spectroscopy:

   Due to its relatively simple structure and spectral properties, ACN is often used as a solvent in UV-Vis, IR, and NMR spectroscopy.

• Exceptional Purity & Consistency: Our Acetonitrile is manufactured to stringent purity specifications, ensuring optimal and predictable performance in your sensitive analytical and synthesis processes.

• Commitment to Quality & Safety: We adhere to the highest industry standards for quality management, safety, and environmental responsibility across all our operations, ensuring peace of mind for our clients handling this highly flammable and toxic solvent.

Hazards Classification

• GHS Classification: Flammable Liquid (GHS02), Acute Toxicity, Oral (GHS06), Acute Toxicity, Inhalation (GHS06), Acute Toxicity, Dermal (GHS06), Serious Eye Damage (GHS05)

• Hazard Statements: Highly flammable liquid and vapor; harmful if swallowed, inhaled, or in contact with skin; causes serious eye damage.

• UN Number: UN 1648

• Hazard Class: 3 (Flammable Liquids)

• Packing Group: II