4-(2-Chloroacetyl)morpholine

4-(2-Chloroacetyl)morpholine is a chloroacetyl-substituted morpholine derivative used as an organic intermediate in selected pharmaceutical intermediate, fine chemical, and specialty synthesis routes. Its structure combines a morpholine ring with a chloroacetyl group, providing an acyl morpholine framework and a reactive chloroacetamide functionality for downstream transformation.

Basic Information

CAS No.	1440-61-5
EC No.	215-880-3
Linear Formula	C6H10ClNO2
Molecular Weight	163.60
Appearance	White to off-white or light yellow crystalline solid
Melting Point	26-30 °C (lit.)
Boiling point	152-160 °C at 6 Torr (lit.)
Density	1.257 g/mL at 25 °C (lit.)
Solubility	Soluble in common organic solvents such as chloroform and methanol
Storage Conditions	Keep in a cool, dry place, sealed tightly, protected from light and moisture
Chemical Structure

Key Applications

• Organic synthesis intermediate: Can be used as a chloroacetyl morpholine intermediate for introducing morpholinocarbonylmethyl functionality in selected organic synthesis routes.

• Fine chemical synthesis: May be evaluated in the preparation of specialty amides, functionalized derivatives, and acyl morpholine intermediates.

• Pharmaceutical intermediate: Used as a morpholine-based intermediate in selected pharmaceutical intermediate synthesis routes, depending on the target structure and specification requirements.

• Research and route development: Suitable for exploratory synthesis, route screening, and intermediate evaluation involving chloroacetamide or morpholine-containing structures.

• Specialty synthesis applications: May support process evaluation for fine chemical and specialty intermediate projects involving substitution, acylation, or chloroacetamide-based transformation steps.

Related Heterocycle Intermediates

Buyers sourcing acyl morpholine or chloroacetyl morpholine derivatives may also review related morpholine intermediates such as 4-Acetylmorpholine CAS 1696-20-4, 4-Phenylmorpholine CAS 92-53-5, and 4-(2-Hydroxyethyl)morpholine CAS 622-40-2.

For related chloroalkyl or functionalized morpholine intermediates, buyers may also compare 4-(3-Chloropropyl)morpholine CAS 7357-67-7, 4-(2-Chloroethyl)morpholine hydrochloride CAS 3647-69-6, and 4-(2-Aminoethyl)morpholine CAS 2038-03-1.

• Sourcing feasibility review: Availability, lead time, and order quantity are confirmed according to the specific product, supplier batch, and current market conditions.

• SDS and COA support: Available safety data sheets and certificates of analysis can be provided upon request, subject to the specific supplier, batch, and grade.

• Packaging and export coordination: Packaging format, labeling, documentation, and shipping terms can be discussed according to product properties, order quantity, and destination requirements.