1,4-Bis(2-hydroxyethyl)piperazine

1,4-Bis(2-hydroxyethyl)piperazine is a bis-hydroxyethyl substituted piperazine derivative used as an organic intermediate in selected pharmaceutical intermediate, fine chemical, and specialty synthesis routes. Its structure contains a piperazine ring with hydroxyethyl groups attached to both nitrogen atoms, providing diol functionality and a piperazine-based framework for downstream transformation.

Basic Information

CAS No.	122-96-3
EC No.	204-586-0
Linear Formula	C8H18N2O2
Molecular Weight	174.24
Appearance	White to off-white crystalline solid
Melting Point	133-136 °C (lit.)
Boiling point	215-220 °C at 50 mm Hg (lit.)
Density	1.097 g/cm³ (lit.)
Solubility	Soluble in water and polar organic solvents
Storage Conditions	Keep in a cool, dry place, sealed tightly, protected from light and moisture
Chemical Structure

Key Applications

• Organic synthesis intermediate: Can be used as a bis-hydroxyethyl piperazine intermediate in selected esterification, etherification, coupling, or derivatization routes involving the hydroxyethyl groups.

• Fine chemical synthesis: May be evaluated in the preparation of specialty chemicals, functionalized piperazine derivatives, and diol-containing organic intermediates.

• Pharmaceutical intermediate: Used as a piperazine-based intermediate in selected pharmaceutical intermediate synthesis routes, depending on the target structure and specification requirements.

• Research and route development: Suitable for exploratory synthesis, route screening, and intermediate evaluation involving bis-hydroxyethyl piperazine structures.

• Specialty synthesis applications: May support process evaluation for fine chemical and specialty intermediate projects involving diol functionality, alcohol derivatization, or piperazine ring modification.

Related Heterocycle Intermediates

Buyers sourcing hydroxyethyl or bis-hydroxyethyl piperazine derivatives may also review related piperazine intermediates such as 1-(2-Hydroxyethyl)piperazine CAS 103-76-4, 1-(2-Hydroxyethyl)-4-methylpiperazine CAS 5464-12-0, and 4-Methyl-1-piperazinepropanol CAS 5317-33-9.

• Sourcing feasibility review: Availability, lead time, and order quantity are confirmed according to the specific product, supplier batch, current market conditions, and destination requirements.

• SDS and COA support: Available safety data sheets and certificates of analysis can be provided upon request, subject to the specific supplier, batch, and grade.

• Packaging and export coordination: Packaging format, labeling, documentation, and shipping terms can be discussed according to product properties, order quantity, and destination requirements.