Guaiacol glycidyl ether

Guaiacol glycidyl ether (CAS 2210-74-4) is a reactive epoxide intermediate featuring an aryloxypropyl chain attached to a methoxy-substituted benzene ring. The glycidyl moiety enables controlled ring-opening reactions that introduce specific ether linkages in target molecules.

Basic Information

CAS No.	2210-74-4
EC No.	Not available
Linear Formula	C10H12O3
Molecular Weight	180.20
Appearance	White to off-white crystalline solid
Melting Point	33-36 °C (lit.)
Boiling point	152-158 °C (lit.)
Density	1.142 g/cm³ (lit.)
Solubility	Soluble in common organic solvents (ethanol, chloroform, dichloromethane)
Storage Conditions	Store sealed in dry conditions at room temperature. Protect from moisture and light.
Chemical Structure

Key Applications

• Epoxide building block for synthesis: Guaiacol glycidyl ether is a highly reactive epoxide intermediate used in ring-opening reactions to introduce aryloxypropyl ether linkages into organic molecules. It is a representative product in Glycidyl Ethers and Epoxy Propyl Ethers for API Synthesis, where epoxide functionality enables versatile downstream transformations.

• Aromatic ether functionalization: The guaiacol-derived aromatic structure provides additional functionality and reactivity, supporting the design of complex molecules with both aromatic and ether characteristics. This application is part of the broader glycidyl ether application category.

• Pharmaceutical intermediate: Widely used as a key intermediate in the synthesis of pharmaceutical compounds such as ranolazine, where controlled epoxide ring-opening reactions enable precise molecular construction.

• Fine chemical intermediate: Employed in the preparation of specialty chemicals and advanced intermediates requiring both aromatic functionality and reactive epoxide groups.

• Laboratory research: Applied in research for developing new synthetic methodologies, particularly in epoxide chemistry and functional molecule design.

• Process development: Supports route optimization and scale-up in processes requiring reliable glycidyl ether intermediates with consistent reactivity and performance.

Guaiacol glycidyl ether belongs to the Glycidyl Ethers & Epoxy Building Blocks application category and is part of our broader portfolio of Ethers for Pharmaceutical Intermediates & Specialty Synthesis, covering reactive epoxide intermediates, aromatic ether derivatives, and advanced building blocks for API and fine chemical synthesis.

• Flexible global supply: Stable international logistics networks support laboratory, pilot, and bulk procurement with reliable delivery to fine chemical customers worldwide.

• SDS and COA support: Complete SDS, COA, and technical documentation available upon request to facilitate quality review and regulatory compliance.

• Packaging and technical service: Flexible packaging options in 25L/200L HDPE drum, backed by responsive technical assistance for synthesis applications.